Rhamnogalacturonan from Acmella oleracea (L.) RK Jansen: Gastroprotective and Ulcer Healing Properties in Rats

被引：40
|
作者：
Maria-Ferreira, Daniele [1 ]
Da Silva, Luisa Mota [1 ]
Gasparin Bueno Mendes, Daniel Augusto [1 ]
Cabrini, Daniela de Almeida [1 ]
Nascimento, Adamara Machado [2 ]
Iacomini, Marcello [2 ]
Cipriani, Thales Ricardo [2 ]
Soares Santos, Adair Roberto [3 ]
de Paula Werner, Maria Fernanda [1 ]
Baggio, Cristiane Hatsuko [1 ]
机构：
[1] Univ Fed Parana, Dept Pharmacol, Sect Biol Sci, BR-80060000 Curitiba, Parana, Brazil
[2] Univ Fed Parana, Dept Biochem & Mol Biol, Sect Biol Sci, BR-80060000 Curitiba, Parana, Brazil
[3] Univ Fed Santa Catarina, Dept Physiol Sci, Ctr Biol Sci, Florianopolis, SC, Brazil
来源：
PLOS ONE | 2014年 / 9卷 / 01期
关键词：
SPILANTHES-ACMELLA; GASTRIC-ULCER; GASTROINTESTINAL-TRACT; POLYSACCHARIDES; MECHANISMS; EXTRACT; QUALITY; TISSUE; OXYGEN;
D O I：
10.1371/journal.pone.0084762
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
A rhamnogalacturonan (RGal) isolated from Acmella oleracea (L.) R.K. Jansen administered by oral route showed gastroprotective activity against acute lesions induced by ethanol. In this study, we investigated the gastric ulcer healing effect of RGal and its mechanisms of action. Intraperitoneal treatment of animals with RGal protected the gastric mucosa against acute lesions induced by ethanol, with participation of gastric mucus. Furthermore, in the chronic ulcer model, oral administration of RGal accelerates the gastric ulcer healing, accompanied by increasing of cellular proliferation and gastric mucus content, reducing inflammatory parameters and oxidative stress. In addition, the repeated 7 days-treatment of animals with RGal did not show alterations of clinical and behavioral symptoms, body and organs weights or plasmatic biochemical parameters. Collectively, these results showed that RGal has an interesting antiulcerogenic activity and could constitute an attractive molecule of interest for the development of new antiulcer agents.
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页数：11
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