Are red blood cell transfusions associated with nosocomial infections in critically ill children?

被引：0

作者：

Naveda Romero, Omar E. ^{[1
]}

Naveda Melendez, Andrea F. ^{[1
]}

机构：

[1] Hosp Univ Pediat Dr Agustin Zubillaga, Dept Shock Trauma & Stabilizat, Barquisimeto, Lara State, Venezuela

来源：

ARCHIVOS ARGENTINOS DE PEDIATRIA | 2016年 / 114卷 / 04期

关键词：

blood transfusion; red blood cells; nosocomial infections; children; STREAM INFECTIONS; CARE-UNIT; IMMUNOMODULATION; PNEUMONIA; ANEMIA;

D O I：

10.5546/aap.2016.eng.347

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Although the transfusion of blood products is common practice, its effects on the immune system have not been adequately studied. A prospective cohort study was conducted in critically ill children followed up until their death, transfer or discharge to establish an association between red blood cell transfusions (RBCTs) and nosocomial infections. A nosocomial infection was considered to be post-transfusional if it occurred within 14 days after RBCT. A total of 162 children were included in the study, 35 (21.6%) had a nosocomial infection, and 49 (30.2%) received a RBCT. Among those with a nosocomial infection, a RBCT was more common (48.5% versus 14.9%, OR: 5.4, 95% CI: 2.4-12.6, p < 0.0001) and mortality rate was higher (45.7% versus 10.2%, OR: 7.4, 95% CI: 3.1-18.2, p < 0.0001). The binary logistic regression showed that RBCT was independently associated with nosocomial infections (OR: 4.2, 95% CI: 2.1-20.2, p=0.049). Conclusion: RBCT was associated with increased risk for nosocomial infections.

引用

页码：347 / 350

页数：4

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