Construction and characterization of a full-length HIV-192UG001 subtype D infectious molecular clone

被引：8
|
作者：
Novelli, P
Vella, C
Oxford, J
Daniels, RS
机构：
[1] Natl Inst Med Res, Div Virol, London NW7 1AA, England
[2] Univ London Queen Mary & Westfield Coll, Dept Med Microbiol, St Bartholomews & Royal London Sch Med & Dent, London E1 2AD, England
[3] Univ London Queen Mary & Westfield Coll, St Bartholomews & Royal London Sch Med & Dent, Retroscreen Ltd, London E1 2AD, England
[4] Univ N London, Sch Biol & Appl Sci, London N7 8DB, England
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2002年 / 18卷 / 01期
关键词：
D O I：
10.1089/088922202753394754
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Here we report the construction, sequencing, and biological characterization of a molecular clone of HIV-1(92UG001), a virus representative of subtype D strains circulating in Uganda. The virus produced by the clone has an aggressive syncytium-inducing phenotype, which matches that of the parental virus. This phenotype may be related to duplication of a binding site for a transcription factor, T cell factor 1alpha (TCF-1alpha), in the long terminal repeat of the virus.
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页码：85 / 88
页数：4
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