共 50 条
- [1] THROMBIN-INDUCED ALTERATIONS IN ENDOTHELIAL PERMEABILITYANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1986, 485 : 293 - 309MALIK, AB论文数: 0 引用数: 0 h-index: 0LO, SK论文数: 0 引用数: 0 h-index: 0BIZIOS, R论文数: 0 引用数: 0 h-index: 0
- [2] INHIBITION BY BERAPROST SODIUM OF THROMBIN-INDUCED INCREASE IN ENDOTHELIAL MACROMOLECULAR PERMEABILITYPROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1995, 53 (02): : 103 - 108IMAISASAKI, R论文数: 0 引用数: 0 h-index: 0机构: Toray Industries Inc., Basic Research Laboratories, Kamakura, Kanagawa-ken, 248KAINOH, M论文数: 0 引用数: 0 h-index: 0机构: Toray Industries Inc., Basic Research Laboratories, Kamakura, Kanagawa-ken, 248OGAWA, Y论文数: 0 引用数: 0 h-index: 0机构: Toray Industries Inc., Basic Research Laboratories, Kamakura, Kanagawa-ken, 248OHMORI, E论文数: 0 引用数: 0 h-index: 0机构: Toray Industries Inc., Basic Research Laboratories, Kamakura, Kanagawa-ken, 248ASAI, Y论文数: 0 引用数: 0 h-index: 0机构: Toray Industries Inc., Basic Research Laboratories, Kamakura, Kanagawa-ken, 248NAKADATE, T论文数: 0 引用数: 0 h-index: 0机构: Toray Industries Inc., Basic Research Laboratories, Kamakura, Kanagawa-ken, 248
- [3] Dabigatran reduces endothelial permeability through inhibition of thrombin-induced cytoskeleton reorganizationTHROMBOSIS RESEARCH, 2018, 167 : 165 - 171论文数: 引用数: h-index:机构:Kim, Na-Eun论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaKim, Jayoung论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaAn, Sunho论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Brain Korea Plus Project Med Sci 21, Seoul 03722, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaYang, Seung-Hee论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaHa, Jimin论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Brain Korea Plus Project Med Sci 21, Seoul 03722, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaCho, Sunghee论文数: 0 引用数: 0 h-index: 0机构: Burke Cornell Med Res Inst, White Plains, NY 10605 USA Weill Cornell Med Coll, Feil Family Brain & Mind Res Inst, New York, NY 10021 USA Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaKwon, Il论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South KoreaKim, Young Dae论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea论文数: 引用数: h-index:机构:Heo, Ji Hoe论文数: 0 引用数: 0 h-index: 0机构: Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea Yonsei Univ, Coll Med, Dept Neurol, 50-1 Yonsei Ro, Seoul 120752, South Korea Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea Yonsei Univ, Brain Korea Plus Project Med Sci 21, Seoul 03722, South Korea Yonsei Univ, Coll Med, Severance Integrat Res Inst Cerebral & Cardiovasc, Seoul, South Korea
- [4] INVOLVEMENT OF TRPV4 CHANNEL IN ENDOTHELIAL DYSFUNCTIONJOURNAL OF VASCULAR RESEARCH, 2009, 46 : 191 - 191Munehisa, Yoshiko论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, JapanWatanabe, Hiroyuki论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, JapanOno, Kyoichi论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Sch Med, Dept Physiol, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, JapanOhba, Takayoshi论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Sch Med, Dept Physiol, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, JapanNobori, Kiyoshi论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, JapanMurakami, Manabu论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Sch Med, Dept Physiol, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, JapanIto, Hiroshi论文数: 0 引用数: 0 h-index: 0机构: Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, Japan Akita Univ, Dept Internal Med, Div Cardiovasc, Akita 010, Japan
- [5] Endothelial TRPV4 channel mediates the vasodilation induced by Tanshinone IIACHEMICO-BIOLOGICAL INTERACTIONS, 2024, 402Wang, Pei论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R China Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing 210029, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaGu, Yuanyuan论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing 210029, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaLu, Jingping论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R China Nanjing Univ Chinese Med, Clin Med Coll 1, Nanjing 210029, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaSong, Miaomiao论文数: 0 引用数: 0 h-index: 0机构: Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Med, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 211166, Peoples R China Nanjing Med Univ, Dept Physiol, Nanjing 211166, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaHou, Wei论文数: 0 引用数: 0 h-index: 0机构: Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Med, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 211166, Peoples R China Nanjing Med Univ, Dept Physiol, Nanjing 211166, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaLi, Pengpeng论文数: 0 引用数: 0 h-index: 0机构: Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Med, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 211166, Peoples R China Nanjing Med Univ, Dept Physiol, Nanjing 211166, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaSun, Yu论文数: 0 引用数: 0 h-index: 0机构: Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Med, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 211166, Peoples R China Nanjing Med Univ, Dept Physiol, Nanjing 211166, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaWang, Juejin论文数: 0 引用数: 0 h-index: 0机构: Nanjing Med Univ, Collaborat Innovat Ctr Cardiovasc Dis Translat Med, Key Lab Targeted Intervent Cardiovasc Dis, Nanjing 211166, Peoples R China Nanjing Med Univ, Dept Physiol, Nanjing 211166, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R ChinaChen, Xiaohu论文数: 0 引用数: 0 h-index: 0机构: Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R China Nanjing Univ Chinese Med, Jiangsu Prov Hosp Chinese Med, Affiliated Hosp, Dept Cardiol, Nanjing 210029, Peoples R China
- [6] Molecular Mechanisms of Thrombin-Induced Endothelial Cell PermeabilityBiochemistry (Moscow), 2002, 67 : 75 - 84N. V. Bogatcheva论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins University,School of MedicineJ. G. N. Garcia论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins University,School of MedicineA. D. Verin论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins University,School of Medicine
- [7] ATP antagonism of thrombin-induced endothelial barrier permeabilityCARDIOVASCULAR RESEARCH, 2003, 59 (02) : 470 - 478Gündüz, D论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanyHirche, F论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanyHärtel, FV论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanyRodewald, CW论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanySchäfer, M论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanyPfitzer, G论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanyPiper, HM论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, GermanyNoll, T论文数: 0 引用数: 0 h-index: 0机构: Univ Giessen, Inst Physiol, D-35392 Giessen, Germany
- [8] Molecular mechanisms of thrombin-induced endothelial cell permeabilityBIOCHEMISTRY-MOSCOW, 2002, 67 (01) : 75 - 84Bogatcheva, NV论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USAGarcia, JGN论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USAVerin, AD论文数: 0 引用数: 0 h-index: 0机构: Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA Johns Hopkins Univ, Sch Med, Baltimore, MD 21224 USA
- [9] Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates SeizuresNEUROTHERAPEUTICS, 2022, 19 (02) : 660 - 681Zeng, Meng-liu论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaCheng, Jing-jing论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaKong, Shuo论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaYang, Xing-liang论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaJia, Xiang-lei论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaCheng, Xue-lei论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaChen, Ling论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Inst Forens Med, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaHe, Fang-gang论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Inst Forens Med, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaLiu, Yu-min论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Zhongnan Hosp, Dept Neurol, Donghu Rd 169, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaFan, Yuan-teng论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Zhongnan Hosp, Dept Neurol, Donghu Rd 169, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaGongga, Lanzi论文数: 0 引用数: 0 h-index: 0机构: Tibet Univ, Med Coll, Lhasa 850000, Tibet, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaChen, Tao-xiang论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaLiu, Wan-hong论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Immunol, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaHe, Xiao-hua论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Pathophysiol, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R ChinaPeng, Bi-wen论文数: 0 引用数: 0 h-index: 0机构: Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China Wuhan Univ, Sch Basic Med Sci, Dept Physiol, Hubei Prov Key Lab Dev Originated Dis, Donghu Rd185, Wuhan 430071, Hubei, Peoples R China
- [10] Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) Mitigates SeizuresNeurotherapeutics, 2022, 19 : 660 - 681Meng-liu Zeng论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesJing-jing Cheng论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesShuo Kong论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesXing-liang Yang论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesXiang-lei Jia论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesXue-lei Cheng论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesLing Chen论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesFang-gang He论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesYu-min Liu论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesYuan-teng Fan论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesLanzi Gongga论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesTao-xiang Chen论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesWan-hong Liu论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesXiao-hua He论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical SciencesBi-wen Peng论文数: 0 引用数: 0 h-index: 0机构: Wuhan University,Department of Physiology, Hubei Provincial Key Laboratory of Developmentally Originated Disease, School of Basic Medical Sciences