A phase I-II trial of Ispinesib, a kinesin spindle protein inhibitor, dosed every two weeks in patients with locally advanced or metastatic breast cancer previously untreated with chemotherapy for metastatic disease or recurrence.

被引:0
|
作者
Gomez, H.
Castaneda, C.
Philco, M.
Pimentel, P.
Falcon, S.
Escandon, R.
Saikali, K.
Conlan, M.
Seroogy, J.
Wolff, A.
机构
[1] Inst Nacl Enfermedades Neoplasicas, Lima, Peru
[2] Hosp Nacl Alberto Sabogal Sologuren, Lima, Peru
[3] Hosp Nacl Edgardo Rebagliati Martins, Lima, Peru
[4] Cytokinet Inc, San Francisco, CA USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:199S / 200S
页数:2
相关论文
共 50 条
  • [1] A Phase I-II Trial of Ispinesib, a Kinesin Spindle Protein Inhibitor, Dosed Every Two Weeks as First Line Chemotherapy for Advanced Locally Recurrent or Metastatic Breast Cancer.
    Gomez, H.
    Philco, M.
    Pimentel, P.
    Escandon, R.
    Saikali, K.
    Seroogy, J.
    Wolff, A.
    Conlan, M.
    CANCER RESEARCH, 2009, 69 (24) : 857S - 857S
  • [2] A phase I/II trial of ispinesib, a kinesin spindle protein (KSP) inhibitor, dosed q14d in patients with advanced breast cancer previously untreated with chemotherapy for metastatic disease or recurrence
    Gomez, H. L.
    Philco, M.
    Castaneda, C.
    Pimentel, P.
    Escandon, R.
    Seroogy, J.
    Saikali, K.
    Wolff, A.
    Conlan, M.
    JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (15)
  • [3] A phase I-II open-label trial of ispinesib on an alternate dosing schedule in chemotherapy-naive patients with locally advanced or metastatic breast cancer (MBC)
    Philco, M.
    Falcon, S.
    Gomez, H.
    Escandon, R.
    Saikali, K.
    Wolff, A.
    JOURNAL OF CLINICAL ONCOLOGY, 2008, 26 (15)
  • [4] A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours
    S P Blagden
    L R Molife
    A Seebaran
    M Payne
    A H M Reid
    A S Protheroe
    L S Vasist
    D D Williams
    C Bowen
    S J Kathman
    J P Hodge
    M M Dar
    J S de Bono
    M R Middleton
    British Journal of Cancer, 2008, 98 : 894 - 899
  • [5] A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours
    Blagden, S. P.
    Molife, L. R.
    Seebaran, A.
    Payne, M.
    Reid, A. H. M.
    Protheroe, A. S.
    Vasist, L. S.
    Williams, D. D.
    Bowen, C.
    Kathman, S. J.
    Hodge, J. P.
    Dar, M. M.
    de Bono, J. S.
    Middleton, M. R.
    BRITISH JOURNAL OF CANCER, 2008, 98 (05) : 894 - 899
  • [6] A phase II trial of capecitabine in previously untreated patients with advanced and/or metastatic gastric cancer
    Hong, YS
    Song, SY
    Lee, SI
    Chung, HC
    Choi, SH
    Noh, SH
    Park, JN
    Han, JY
    Kang, JH
    Lee, KS
    Cho, JY
    ANNALS OF ONCOLOGY, 2004, 15 (09) : 1344 - 1347
  • [7] Intravenous azidothymidine with fluorouracil and leucovorin: A phase I-II study in previously untreated metastatic colorectal cancer patients
    Falcone, A
    Danesi, R
    Dargenio, F
    Pfanner, E
    Brunetti, I
    DelTacca, M
    Nethersell, ABW
    Conte, PF
    JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (03) : 729 - 736
  • [8] Phase I-II trial of tipifarnib plus cyclophosphamide and doxorubicin in patients with metastatic and locally advanced breast cancer: clinical and molecular effects.
    Sparano, JA
    Vahdat, L
    Moulder, S
    Kazi, A
    Sebti, S
    BREAST CANCER RESEARCH AND TREATMENT, 2004, 88 : S64 - S64
  • [9] Phase II study of calcitriol-enhanced docetaxel in patients with previously untreated metastatic or locally advanced pancreatic cancer
    Blanke, C. D.
    Beer, T. M.
    Todd, K.
    Mori, M.
    Stone, M.
    Lopez, C.
    INVESTIGATIONAL NEW DRUGS, 2009, 27 (04) : 374 - 378
  • [10] Phase II study of calcitriol-enhanced docetaxel in patients with previously untreated metastatic or locally advanced pancreatic cancer
    C. D. Blanke
    T. M. Beer
    K. Todd
    M. Mori
    M. Stone
    C. Lopez
    Investigational New Drugs, 2009, 27 : 374 - 378