In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway

被引：6

作者：

da Silva, Marcia F. ^{[1
]}

Saito, Alexandre Y. ^{[1
]}

Peres, Valnice J. ^{[1
]}

Oliveira, Antonio C. ^{[2
]}

Katzin, Alejandro M. ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Sao Paulo, Brazil

[2] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 08期

基金：

巴西圣保罗研究基金会;

关键词：

INTRAERYTHROCYTIC STAGES; BIOSYNTHESIS; SYNTHASE; DRUG; CLONING;

D O I：

10.1128/AAC.04161-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Previous studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro. We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects.

引用

页码：5084 / 5087

页数：4

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