Sporozoite and liver stage antigen Plasmodium falciparum peptides bind specifically to human hepatocytes

被引：14
|
作者：
Puentes, A
García, J
Vera, R
López, R
Suarez, J
Rodríguez, L
Curtidor, H
Ocampo, M
Tovar, D
Forero, M
Bermudez, A
Cortes, J
Urquiza, M
Patarroyo, ME
机构：
[1] Fdn Inst Inmunol Colombia, Bogota 2600, Colombia
[2] Univ Nacl Colombia, Bogota 2600, Colombia
来源：
VACCINE | 2004年 / 22卷 / 9-10期
关键词：
Plasmodium falciparum; SALSA protein; binding peptides; critical residues; hepatocyte binding peptides;
D O I：
10.1016/j.vaccine.2003.09.029
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Sporozoite and Liver Stage Antigen (SALSA) sequence synthetic peptides were used in HepG2 cell binding assays to identify regions involved in parasite invasion. SALSA 20608 ((21)IWASEKKDEKEASEQGEESHY(40)) and 20611 ((64)KKDDGTDKVQEKVLEKSPKY(83)) peptides were determined as having high binding activity in HepG2 cell assays, some of them were located in immunogenic regions. Immune-fluorescence antibody test with 24276 (20608 peptide analogue, CGIWSSMKMDEKMAAMQGEESHCG) showed sporozoite and merozoite reactivity. This data suggests SALSA high activity binding peptides' (HABPs) possible role in hepatic cell invasion and merozoite invasion of erythrocytes. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1150 / 1156
页数：7
相关论文
共 50 条
  • [1] Peptides of the liver stage antigen-1 (LSA-1) of Plasmodium falciparum bind to human hepatocytes
    García, JE
    Puentes, A
    López, R
    Vera, R
    Suárez, J
    Rodríguez, L
    Curtidor, H
    Ocampo, M
    Tovar, D
    Forero, M
    Bermudez, A
    Cortés, J
    Urquiza, M
    Patarroyo, ME
    [J]. PEPTIDES, 2003, 24 (05) : 647 - 657
  • [2] Peptides of the liver stage antigen-1 (LSA-1) of Plasmodium falciparum bind to human hepatocytes (vol 24, pg 647, 2003)
    García, JE
    Puentes, A
    López, R
    Vera, R
    Suárez, J
    Rodríguez, L
    Curtidor, H
    Ocampo, M
    Tovar, D
    Forero, M
    Bermudez, A
    Cortés, J
    Urquiza, M
    Patarroyo, ME
    [J]. PEPTIDES, 2003, 24 (09) : 1453 - 1453
  • [3] Liver stage antigen 3 Plasmodium falciparum peptides specifically interacting with HepG2 cells
    García, JE
    Curtidor, H
    López, R
    Rodríguez, L
    Vera, R
    Valbuena, J
    Rosas, J
    Ocampo, M
    Puentes, A
    Forero, M
    Patarroyo, MA
    Patarroyo, ME
    [J]. JOURNAL OF MOLECULAR MEDICINE-JMM, 2004, 82 (09): : 600 - 611
  • [4] Liver stage antigen 3 Plasmodium falciparum peptides specifically interacting with HepG2 cells
    Javier E. García
    Hernando Curtidor
    Ramses López
    Luis Rodríguez
    Ricardo Vera
    John Valbuena
    Jaiver Rosas
    Marisol Ocampo
    Alvaro Puentes
    Martha Forero
    Manuel A. Patarroyo
    Manuel Elkin Patarroyo
    [J]. Journal of Molecular Medicine, 2004, 82 : 600 - 611
  • [5] Amino terminal peptides of the ring infected erythrocyte surface antigen of Plasmodium falciparum bind specifically to erythrocytes
    Bravo, RV
    Marín, V
    García, J
    Urquiza, M
    Torres, E
    Trujillo, M
    Rosas, J
    Patarroyo, ME
    [J]. VACCINE, 2000, 18 (14) : 1289 - 1293
  • [6] Synthetic peptides from Plasmodium falciparum apical membrane antigen 1 (AMA-1) specifically interacting with human hepatocytes
    Valbuena, J.
    Rodriguez, L.
    Vera, R.
    Puentes, A.
    Curtidor, H.
    Cortes, J.
    Rosas, J.
    Patarroyo, M. E.
    [J]. BIOCHIMIE, 2006, 88 (10) : 1447 - 1455
  • [7] Plasmodium falciparum normocyte binding protein (PfNBP-1) peptides bind specifically to human erythrocytes
    Valbuena, JJ
    Vera, R
    García, J
    Puentes, A
    Curtidor, H
    Ocampo, M
    Urquiza, M
    Rivera, Z
    Guzmán, F
    Torres, E
    Patarroyo, ME
    [J]. PEPTIDES, 2003, 24 (07) : 1007 - 1014
  • [8] DNA immunization by Plasmodium falciparum liver-stage antigen 3 induces protection against Plasmodium yoelii sporozoite challenge
    Sauzet, JP
    Perlaza, BL
    Brahimi, K
    Daubersies, P
    Druilhe, P
    [J]. INFECTION AND IMMUNITY, 2001, 69 (02) : 1202 - 1206
  • [9] A BLOOD STAGE ANTIGEN OF PLASMODIUM-FALCIPARUM SHARES DETERMINANTS WITH THE SPOROZOITE COAT PROTEIN
    COPPEL, RL
    FAVALORO, JM
    CREWTHER, PE
    BURKOT, TR
    BIANCO, AE
    STAHL, HD
    KEMP, DJ
    ANDERS, RF
    BROWN, GV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (15) : 5121 - 5125
  • [10] MAEBL Plasmodium falciparum protein peptides bind specifically to erythrocytes and inhibit in vitro merozoite invasion
    Ocampo, M
    Curtidor, H
    Vera, R
    Valbuena, JJ
    Rodríguez, LE
    Puentes, A
    López, R
    García, JE
    Tovar, D
    Pacheco, P
    Navarro, MA
    Patarroyo, ME
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 315 (02) : 319 - 329
12345