Some historical figures have suffered endocrine diseases. This review relates those whose diseases have been published in the scientific literature. It takes a biographical summary and describes the disease process in those considered most relevant by the nature of the disease or the importance of the figure in the Spanish and Latin American context: the Pharaoh Akhenaten, Maximinus I, Bodhidharma, Sancho I of Leon, William the Conqueror, Enrique IV of Castile, Henry VIII, Mary Tudor, Carlos II of Spain, Pio Pico, Pedro II of Brazil, Eisenhower and J. F. Kennedy. (C) 2013 SEEN. Published by Elsevier Espana, S.L.U. All rights reserved.