Complex genetics of drug resistance in Mycobacterium tuberculosis

被引：20
|
作者：
Warner, Digby F. [1 ]
Mizrahi, Valerie [1 ]
机构：
[1] Univ Cape Town, NHLS, MRC, Mol Mycobacteriol Res Unit, ZA-7700 Rondebosch, South Africa
来源：
NATURE GENETICS | 2013年 / 45卷 / 10期
关键词：
D O I：
10.1038/ng.2769
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.
引用
收藏
页码：1107 / 1108
页数：3
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