The direct conversion of carbamates to ureas using aluminum amides

被引：51
|
作者：
Lee, SH [1 ]
Matsushita, H [1 ]
Clapham, B [1 ]
Janda, KD [1 ]
机构：
[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
TETRAHEDRON | 2004年 / 60卷 / 15期
关键词：
ureas; carbamate; Lewis acid;
D O I：
10.1016/j.tet.2004.02.034
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The conversion of carbamates into ureas using aluminum amide complexes is reported. This reaction is a convenient method to prepare bi-, tri- and tetra-substituted ureas from carbamate-protected primary or secondary amines by reaction with primary or secondary amines in the presence of stoichometric quantities of trimethylaluminum. A reactivity trend of the various carbamates was observed and methyl and benzyl carbamates were reacted selectively in the presence of t-butyl carbamates. (C) 2004 Elsevier Ltd. All rights reserved.
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收藏
页码：3439 / 3443
页数：5
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