Cab45 is required for Ca2+-dependent secretory cargo sorting at the trans-Golgi network

被引：73

作者：

von Blume, Julia ^{[1
]}

Alleaume, Anne-Marie ^{[2
,5
]}

Kienzle, Christine ^{[1
]}

Carreras-Sureda, Amado ^{[3
]}

Valverde, Miguel ^{[3
]}

Malhotra, Vivek ^{[2
,4
]}

机构：

[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[2] Ctr Genom Regulat CRG, Barcelona 08003, Spain

[3] UPF, Barcelona 08003, Spain

[4] ICREA, Barcelona 08010, Spain

[5] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

JOURNAL OF CELL BIOLOGY | 2012年 / 199卷 / 07期

基金：

欧洲研究理事会;

关键词：

RETROGRADE TRANSPORT; VACUOLAR HYDROLASES; CA2+ HOMEOSTASIS; COATED VESICLES; KDEL RECEPTOR; PROTEINS; YEAST; PATHWAY; TGN; COMPARTMENT;

D O I：

10.1083/jcb.201207180

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ca2+ import into the lumen of the trans-Golgi network (TGN) by the secretory pathway calcium ATPase1 (SPCA1) is required for the sorting of secretory cargo. How is Ca2+ retained in the lumen of the Golgi, and what is its role in cargo sorting? We show here that a soluble, lumenal Golgi resident protein, Cab45, is required for SPCA1-dependent Ca2+ import into the TGN; it binds secretory cargo in a Ca2+-dependent reaction and is required for its sorting at the TGN.

引用

页码：1057 / 1066

页数：10

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