The efficacy of topiramate (topamax) in the treatment of resistant epilepsy in children

被引：0
|
作者：
Dorofeeva, MY [1 ]
Ermakov, A [1 ]
Belousova, ED [1 ]
机构：
[1] Moscow Sci Res Inst Pediat & Pediat Surg, Moscow, Russia
来源：
ZHURNAL NEVROLOGII I PSIKHIATRII IMENI S S KORSAKOVA | 2005年 / 105卷 / 11期
关键词：
topiramate; pharmakoresistant epilepsy; tuberous sclerosis; children;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Authors presented the data on the efficacy and tolerability of the new anticonvulsant drug topiramate (topamax) in the treatment of 110 children aged from 6 months to 16 years with pharmacoresistant types of epilepsy including 42 patients with tuberous sclerosis. The medication dosage varied from 1 to 20 mg/kg daily. As a monotherapy the drug was used in 28 children, in the other cases it was combined with different anticonvulsant medications. Topiramate was effective in 78% patients; complete remission has been achieved in 35% cases. Side-effects were observed in 17% patients but they were transient and did not result in the drug withdrawal. The results of the study allowed to recommend the drug as an add-on and monotherapy in the treatment of resistant epilepsy.
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页码：21 / 23
页数：3
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