Escort Aptamers: New Tools for the Targeted Delivery of Therapeutics into Cells

被引：13
|
作者：
Davydova, A. S. [1 ]
Vorobjeva, M. A. [1 ]
Venyaminova, A. G. [1 ]
机构：
[1] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Moscow 117901, Russia
来源：
ACTA NATURAE | 2011年 / 3卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
SELEX method; NA aptamers; escort aptamers; specific cell binding; addressed cell delivery; detection of cells; IN-VITRO SELECTION; SINGLE-STRANDED-DNA; LIVE AFRICAN TRYPANOSOMES; PROSTATE-CANCER CELLS; NUCLEIC-ACID LIGANDS; STABLE RNA APTAMERS; MUC1; TUMOR-MARKER; SYSTEMATIC EVOLUTION; EXPONENTIAL ENRICHMENT; MOLECULAR RECOGNITION;
D O I：
10.32607/20758251-2011-3-4-12-29
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Escort aptamers are DNA or RNA sequences with high affinity to certain cell-surface proteins, which can be used for targeted delivery of various agents into cells of a definite type. The peculiarities of the selection of escort aptamers are discussed in this review. The methods used in selection of escort aptamers via the SELEX technique are considered, including selection against isolated cell-surface proteins, cell fragments, living eukaryotic cells, and bacteria. Particular attention is given to the design and chemical modification of escort aptamers. The different fields of application of escort aptamers are described, including the targeted delivery of siRNAs, nanoparticles, toxins, and photoagents, as well as the identification of specific cell markers and the detection or isolation of cells of a definite type. The potential for the application of escort aptamers in the development of new therapeutic agents and diagnostic systems is also discussed.
引用
收藏
页码：12 / 29
页数：18
相关论文
共 50 条
  • [1] Non-Invasive Delivery of Therapeutics into the Brain: The Potential of Aptamers for Targeted Delivery
    Bukari, Bakhtiar
    Samarasinghe, Rasika M.
    Noibanchong, Jinjutha
    Shigdar, Sarah L.
    [J]. BIOMEDICINES, 2020, 8 (05)
  • [2] Escort aptamers: a delivery service for diagnosis and therapy
    Hicke, BJ
    Stephens, AW
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (08): : 923 - 928
  • [3] Application of Aptamers for Targeted Therapeutics
    Partha Ray
    Kristi D. Viles
    Erin E. Soule
    Rebecca Smock Woodruff
    [J]. Archivum Immunologiae et Therapiae Experimentalis, 2013, 61 : 255 - 271
  • [4] Application of Aptamers for Targeted Therapeutics
    Ray, Partha
    Viles, Kristi D.
    Soule, Erin E.
    Woodruff, Rebecca Smock
    [J]. ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS, 2013, 61 (04) : 255 - 271
  • [5] Targeted delivery of RNA aptamers to diseased cells
    Roy, I.
    [J]. NEW BIOTECHNOLOGY, 2018, 44 : S24 - S24
  • [6] Aptamers in Therapeutics and Drug Delivery
    Fattal, Elias
    Hillaireau, Herve
    Ismail, Said I.
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2018, 134 : 1 - 2
  • [7] Oligonucleotide Aptamers: New Tools for Targeted Cancer Therapy
    Sun, Hongguang
    Zhu, Xun
    Lu, Patrick Y.
    Rosato, Roberto R.
    Tan, Wen
    Zu, Youli
    [J]. MOLECULAR THERAPY-NUCLEIC ACIDS, 2014, 3
  • [8] Aptamers for Targeted Drug Delivery
    Ray, Partha
    White, Rebekah R.
    [J]. PHARMACEUTICALS, 2010, 3 (06): : 1761 - 1778
  • [9] Aptamers and aptamer targeted delivery
    Yan, Amy C.
    Levy, Matthew
    [J]. RNA BIOLOGY, 2009, 6 (03) : 316 - 320
  • [10] Aptamers as targeted therapeutics: current potential and challenges
    Jiehua Zhou
    John Rossi
    [J]. Nature Reviews Drug Discovery, 2017, 16 : 181 - 202
12345