"Vitamin D and lifestyle intervention for gestational diabetes mellitus prevention". European project for prevention of gestational diabetes

The overall aim of the vitamin D and lifestyle intervention for gestational diabetes mellitus prevention (DALI) project funded by the European Commission is to identify the best available measures to prevent gestational diabetes mellitus (GDM). Additional aims are (1) to provide a cost-benefit calculation of GDM prevention for health care systems, (2) to establish the current status of GDM across Europe and facilitate the adoption of a single diagnostic approach and (3) to establish a pan-European cohort of mother-offspring pairs for future analyses with a central biobank and data base. The consortium comprises 11 partners from academia and 2 small to medium enterprises (SME) from 10 European countries. A randomized controlled trial will be conducted in ten European countries. In each country 100 women with a body mass index (BMI) a parts per thousand yenaEuro parts per thousand 29 will be recruited before the 12th week of pregnancy and followed up for approximately 7 months until delivery. The women will be randomized into two groups with lifestyle interventions and vitamin D supplementation or no intervention. Women receiving lifestyle interventions (e.g. physical activity, diet or a combination) will have personal contact with a lifestyle coach trained in motivational interviewing. The main outcome measures of the trial are fasting blood glucose, weight gain during pregnancy and insulin sensitivity.