K1 and K3 capsular antigens of Klebsiella induce tumor necrosis factor activities

被引：2

作者：

Choy, YM ^{[1
]}

Tsang, SF ^{[1
]}

Kong, SK ^{[1
]}

Leung, KN ^{[1
]}

Parolis, H ^{[1
]}

Lee, CY ^{[1
]}

Fung, KP ^{[1
]}

机构：

[1] RHODES UNIV, SCH PHARMACEUT SCI, GRAHAMSTOWN 6140, SOUTH AFRICA

来源：

LIFE SCIENCES | 1996年 / 58卷 / 09期

关键词：

Klebsiella pneumoniae; K1 and K3 capsular antigens; tumor necrosis factor-alpha;

D O I：

10.1016/0024-3205(95)02361-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Capsular polysaccharide antigens isolated from Klebsiella pneumoniae sere-type 1 (K1) and sere-type 3 (K3) could induce tumor necrosis factor-alpha in ICR mice. K1 and K3 capsular antigens were found to be non-toxic by brine shrimp bioassay. When injected into Ehrlich ascites tumor-bearing mice, both K1 and K3 capsular antigens exhibited significant suppression in the growth of tumor cells. The significance of these observations is discussed.

引用

页码：PL153 / PL158

页数：6

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