ASK1 inhibition triggers platelet apoptosis via p38-MAPK-mediated mitochondrial dysfunction

被引:13
|
作者
Manikanta, Kurnegala [1 ]
NaveenKumar, Somanathapura K. [1 ]
Hemshekhar, Mahadevappa [1 ]
Kemparaju, Kempaiah [1 ]
Girish, Kesturu S. [1 ,2 ]
机构
[1] Univ Mysore, Dept Studies Biochem, Manasagangotri, Mysuru, India
[2] Tumkur Univ, Dept Studies & Res Biochem, Tumakuru, India
关键词
MECHANISMS; KINASES;
D O I
10.3324/haematol.2019.233908
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E419 / E423
页数:5
相关论文
共 50 条
  • [1] Induction of apoptosis by quercetin is mediated through AMPKα1/ASK1/p38 pathway
    Lee, Yun-Kyoung
    Hwang, Jin-Taek
    Kwon, Dae Young
    Surh, Young-Joon
    Park, Ock Jin
    CANCER LETTERS, 2010, 292 (02) : 228 - 236
  • [2] Astragalus polysaccharides ameliorate osteoarthritis via inhibiting apoptosis by regulating ROS-mediated ASK1/p38 MAPK signaling pathway targeting on TXN
    Xu, Jintao
    Yu, Yaohui
    Chen, Kai
    Wang, Yishu
    Zhu, Yi
    Zou, Xiangjie
    Xu, Xianghong
    Jiang, Yiqiu
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 258
  • [3] Vaccarin Ameliorates Doxorubicin-Induced Cardiotoxicity via Inhibition of p38 MAPK Mediated Mitochondrial Dysfunction
    Shi, Xin
    Cao, Yang
    Wang, Hongyu
    Zhao, Qi
    Yan, Cong
    Li, Shengzhu
    Jing, Ling
    JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 2024, 17 (05) : 1155 - 1171
  • [4] Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway
    Zhang, Zhen-Dong
    Yang, Ya-Jun
    Liu, Xi-Wang
    Qin, Zhe
    Li, Shi-Hong
    Li, Jian-Yong
    TOXICOLOGY, 2021, 453
  • [5] Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway
    Tsuchiya, Ayako
    Kaku, Yoshiko
    Nakano, Takashi
    Nishizaki, Tomoyuki
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2015, 129 (03) : 160 - 168
  • [6] Redundant role of ASK1-mediated p38MAPK activation in human platelet function
    Sledz, Kamila M.
    Moore, Samantha F.
    Vijayaragavan, Vijayasameerah
    Mallah, Shahida
    Goudswaard, Lucy J.
    Williams, Christopher M.
    Hunter, Roger W.
    Hers, Ingeborg
    CELLULAR SIGNALLING, 2020, 68
  • [7] APOPTOSIS SIGNAL-REGULATING KINASE 1 (ASK1) ACTIVATES p38 MAPK SIGNALLING AND INDUCES INFLAMMATORY GLOMERULAR INJURY
    Amos, L. A.
    Han, Y.
    Breckenridge, D. G.
    Nikolic-Paterson, D. J.
    NEPHROLOGY, 2014, 19 : 27 - 27
  • [8] The angiotensin receptor neprilysin inhibitor LCZ696 attenuates renal fibrosis via ASK1/JNK/p38 MAPK-mediated apoptosis in unilateral ureteral obstruction
    Ding, Jun
    Cui, Sheng
    Li, Song Yu
    Cui, Lin Yan
    Nan, Qi Yan
    Lin, Xue Jing
    Xuan, Mei Ying
    Jin, Jian
    Piao, Shang Guo
    Jiang, Yu Ji
    Zheng, Hai Lan
    Jin, Ji Zhe
    Chung, Byung Ha
    Yang, Chul Woo
    Cui, Jing Hao
    Li, Can
    PLOS ONE, 2023, 18 (06):
  • [9] ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
    Tobiume, K
    Matsuzawa, A
    Takahashi, T
    Nishitoh, H
    Morita, K
    Takeda, K
    Minowa, O
    Miyazono, K
    Noda, T
    Ichijo, H
    EMBO REPORTS, 2001, 2 (03) : 222 - 228
  • [10] E2F1 modulates p38 MAPK phosphorylation via transcriptional regulation of ASK1 and Wip1
    Hershko, Tzippi
    Korotayev, Katya
    Polager, Shirley
    Ginsberg, Doron
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (42) : 31309 - 31316