Short course of radiation therapy in elderly patients with glioblastoma multiforme

被引：22

作者：

Idbaih, A. ^{[1
,2
]}

Taillibert, S. ^{[1
,2
]}

Simon, J. -M. ^{[1
]}

Psimaras, D. ^{[2
]}

Schneble, H. -M. ^{[3
]}

Lopez, S. ^{[1
]}

Lang, P. ^{[1
]}

Toubiana, T. ^{[1
]}

Feuvret, L. ^{[1
]}

Delattre, J. -Y. ^{[2
]}

Mazeron, J. -J. ^{[1
]}

机构：

[1] Grp Hosp Pitie Salpetriere, AP HP, Serv Radiotherapie Oncol, F-75651 Paris 13, France

[2] Grp Hosp Pitie Salpetriere, AP HP, Serv Neurol Mazarin, F-75651 Paris 13, France

[3] Grp Hosp Lariboisiere, AP HP, Serv Neurol, Paris, France

来源：

CANCER RADIOTHERAPIE | 2008年 / 12卷 / 08期

关键词：

Elderly; Glioblastoma multiforme; Glioma; Karnofsky performance status; Radiotherapy;

D O I：

10.1016/j.canrad.2008.05.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose. - The optimal schedule of irradiation in elderly patients suffering from glioblastoma multiforme (GBM) is unsettled. Materials and methods. - This study reviewed the charts of 28 consecutive GBM patients aged 70 years or more with a Karnofsky Performance Status (KPS) greater than or equal to 70 who received a short course of radiotherapy (40 grays in 15 fractions over three weeks). Results. - The median age at surgery was 74.6 years (range, 70.1-85.7). No patient received prior or concomitant chemotherapy. The median progression-free survival and overall survival were 21.6 weeks (95% Cl, 17.0-39.9) and 50.6 weeks (95% Cl, 26.3-62.0), respectively. Even within a narrow range (<90 or >= 90), KPS remained a prognostic factor (p=0.03). Tolerance appeared acceptable in terms of KPS changes and corticosteroid use during radiation therapy. Conclusion. - These results support the efficacy of short schedule radiotherapy for GBM in elderly patients with a good KPS. (C) 2008 Published by Elsevier Masson SAS.

引用

页码：788 / 792

页数：5

共 50 条

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