Identification of novel small molecule inhibitors of the inducible heat shock protein Hsp70

被引：0
|
作者：
Balaburski, Gregor M. [1 ]
Leu, Julie [2 ]
Hayik, Seth A. [1 ]
Andrake, Mark [1 ]
Dunbrack, Roland [1 ]
George, Donna [2 ]
Murphy, Maureen E. [1 ]
机构：
[1] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
[2] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA
来源：
CANCER RESEARCH | 2011年 / 71卷
关键词：
D O I：
10.1158/1538-7445.AM2011-3771
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3771
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Identification and validation of a novel allosteric pocket on human heat shock protein 70 (Hsp70) homology model for the discovery of Hsp70 inhibitors
    Patel, Pallav D.
    Talele, Tanaji T.
    Taldon, Tony
    Kang, Yanlong
    Shi, Lei
    Chiosis, Gabriela
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [2] Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators
    Huryn, Donna M.
    Brodsky, Jeffrey L.
    Brummond, Kay M.
    Chambers, Peter G.
    Eyer, Benjamin
    Ireland, Alex W.
    Kawasumi, Masaoki
    LaPorte, Matthew G.
    Lloyd, Kayla
    Manteau, Baptiste
    Nghiem, Paul
    Quade, Bettina
    Seguin, Sandlin P.
    Wipf, Peter
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (17) : 6757 - 6762
  • [3] Rational design of small molecule inhibitors that bind to an allosteric pocket on human heat shock protein 70 (Hsp70)
    Taldone, Tony
    Patel, Palay D.
    Kang, Yanlong
    Rodina, Anna
    Talele, Tanaji T.
    Chiosis, Gabriela
    CANCER RESEARCH, 2012, 72
  • [4] A Small Molecule Inhibitor of Inducible Heat Shock Protein 70
    Leu, J. I-Ju
    Pimkina, Julia
    Frank, Amanda
    Murphy, Maureen E.
    George, Donna L.
    MOLECULAR CELL, 2009, 36 (01) : 15 - 27
  • [5] Immunohistochemical detection of the inducible heat shock protein Hsp70: A methodological study
    Malusecka, E
    Zborek, A
    Krzyzowska-Gruca, S
    Krawczyk, Z
    JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 2006, 54 (02) : 183 - 189
  • [6] Targeting novel protein complexes and interrogating small molecule inhibitors of the anticancer target HSP70
    Evans, Lindsay
    Jones, Keith
    Cheeseman, Matthew
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [7] IDENTIFICATION OF HEAT-SHOCK PROTEIN HSP70 HOMOLOGS IN CHLOROPLASTS
    MARSHALL, JS
    DEROCHER, AE
    KEEGSTRA, K
    VIERLING, E
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (01) : 374 - 378
  • [8] Transfection of Heat Shock Protein 70 kDa (HSP70)
    Gestin, Maxime
    Falato, Luca
    Ciccarelli, Michela
    Cerrato, Carmine Pasquale
    Andreasson, Claes
    Langel, Ulo
    INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 2022, 28 (04)
  • [9] The neuroprotective potential of heat shock protein 70 (HSP70)
    Yenari, MA
    Giffard, RG
    Sapolsky, RM
    Steinberg, GK
    MOLECULAR MEDICINE TODAY, 1999, 5 (12): : 525 - 531
  • [10] An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target
    Howe, Matthew K.
    Speer, Brittany L.
    Hughes, Philip E.
    Loiselle, David R.
    Vasudevan, Subhash
    Haystead, Timothy A. J.
    ANTIVIRAL RESEARCH, 2016, 130 : 81 - 92
12345