The M/SAR elements of the bithorax complex in Drosophila melanogaster

被引:0
|
作者
Boykova, TV [1 ]
Orlando, V
Lupo, R
Bogachev, SS
机构
[1] Russian Acad Sci, Inst Cytol & Genet, Novosibirsk 630090, Russia
[2] Ist Sci San Raffaele, Dept Biol & Technol Res, I-20132 Milan, Italy
关键词
D O I
10.1007/s11177-005-0221-7
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The bithorax (BX) complex of Drosophila is a complex polygenic region with a multifactorial system of regulation. One of the levels of the regulatory system of the BX complex is its association with the nuclear skeleton structures through a specific interaction of the M/SAR DNA with the nuclear matrix proteins. In the present work, M/SAR elements were mapped on the molecular-genetic map of the region. All of the elements examined were found to colocalize with regulatory elements and form clusters that restrict/bracket the genetically active domains. All M/SAR DNA revealed was shown to bins specifically to the purified Drosophila melanogaster lamin.
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收藏
页码:1206 / 1216
页数:11
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