Particle Formation and Product Formulation Using Supercritical Fluids

被引:31
|
作者
Knez, Zeljko [1 ]
Hrncic, Masa Knez [1 ]
Skerget, Mojca [1 ]
机构
[1] Univ Maribor, Fac Chem & Chem Engn, SI-2000 Maribor, Slovenia
关键词
micronization; dense gases; antisolvent processes; rapid expansion; spray extraction; PGSS (TM); ACTIVE PHARMACEUTICAL INGREDIENTS; SOLID-LIQUID-GAS; RAPID EXPANSION; CARBON-DIOXIDE; SOLUTIONS RESS; ANTISOLVENT MICRONIZATION; ANTI-SOLVENT; PHASE-EQUILIBRIA; THERMODYNAMIC BEHAVIOR; MOLECULAR-DYNAMICS;
D O I
10.1146/annurev-chembioeng-061114-123317
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Traditional methods for solids processing involve either high temperatures, necessary for melting or viscosity reduction, or hazardous organic solvents. Owing to the negative impact of the solvents on the environment, especially on living organisms, intensive research has focused on new, sustainable methods for the processing of these substances. Applying supercritical fluids for particle formation may produce powders and composites with special characteristics. Several processes for formation and design of solid particles using dense gases have been studied intensively. The unique thermodynamic and fluid-dynamic properties of supercritical fluids can be used also for impregnation of solid particles or for the formation of solid powderous emulsions and particle coating, e.g., for formation of solids with unique properties for use in different applications. We give an overview of the application of sub-and supercritical fluids as green processing media for particle formation processes and present recent advances and trends in development.
引用
收藏
页码:379 / 407
页数:29
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