5-Chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline

被引：4
|
作者：
Luna Parada, Luz Karime [1 ]
Kouznetsov, Vladimir V. [1 ]
机构：
[1] Univ Ind Santander, Lab Quim Organ & Biomol, CMN, Parque Tecnol Guatiguara,Km 2 Via Refugio, Piedecuesta 681011, Colombia
来源：
MOLBANK | 2019年 / 01期
关键词：
4-chloro-8-hydroxyquinoline; triazoles; conjugated triazolyl-quinoline hybrid; CuAAC; Lipinski' descriptors; DERIVATIVES; CHEMISTRY;
D O I：
10.3390/M1038
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The title quinoline derivative, 5-chloro-8-{[1-(2-chlorobenzyl)-1H-1,2,3-triazol-4-yl]methoxy}quinoline, was synthesized in a common three-step procedure from 5-chloro-8-hydroxyquinoline using O-propargylation reaction/copper-catalyzed 1,3-dipolar cycloaddition sequence. The structure of the compound was fully characterized by FT-IR, H-1- and C-13-NMR, GC-MS, and elemental analysis. Its physicochemical parameters (Lipinski's descriptors) were also calculated using the Molinspiration Cheminformatics software. The hybrid obtained could be an interesting model for antifungal bio-essays or a suitable precursor in the synthesis of more complex triazolyl-quinoline hybrids, potential pharmacological agents.
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页数：5
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