EFFICIENT SYNTHESIS OF N-METHYLAMIDES AND AMINES VIA 4-(ALKYLAMINO)BENZYL-N-METHYLAMINE AS A NEW PROTECTING GROUP

被引：1

作者：

Lee, Sang-Hak ^{[1
]}

Mu, Yu ^{[1
]}

Kim, Gun-Woo ^{[1
]}

Kim, Jin-Seok ^{[1
]}

Park, Seok-Hwi ^{[1
]}

Jin, Tian ^{[1
]}

Lee, Kee-Young ^{[2
]}

Ham, Won-Hun ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Pharm, Suwon 440746, South Korea

[2] Yonsung Fine Chem Co Ltd, Hwaseong Si 445944, Gyeonggi Do, South Korea

来源：

HETEROCYCLES | 2013年 / 87卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

BENZYL; DEBENZYLATION; ALLYL;

D O I：

10.3987/COM-13-12747

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-(Alkylamino)benzyl-N-methylamine is a good protecting group for the synthesis of N-methylamides and amines. The N-debenzylation of N-methylamides and amines can be carried out selectively and efficiently under condition using trifluoroacetic acid (TFA).

引用

页码：1749 / 1764

页数：16

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