An elderly patient with primary cervical CD5-positive diffuse large B-cell lymphoma: a case report and review of the literature

Objective: To increase our understanding of the clinical features, diagnosis and treatment, and prognosis of primary cervical CD5+ diffuse large B-cell lymphoma (DLBCL) in an elderly patient. Materials and Methods: We analyzed a case of an elderly patient with primary cervical CD5+ DLBCL and reviewed the literature. Results: The clinical features of this patient were not specific and were manifested as fever, significantly elevated LDH, normal blood test results, an unidentified fraction (6.5%) of cells shown by bone marrow puncture, unexpressed T-system and medullary system markers, and a primary lesion of the cervix found upon positron emission tomography-computed tomography (PET-CT). Cervical biopsy plus immunohistochemical staining showed a CD5+DLBCL, and the diagnosis was confirmed and R-CHOP therapy achieved a favorable therapeutic effect. Conclusions: The clinical manifestations of primary cervical CD5+DLBCL are not specific but PET-CT combined with cervical biopsy can clarify the diagnosis with R-CHOPas the preferred therapeutic regimen.