Syntheses, Characterizations and Antitumor Activities of Two Copper(II) Complexes with an Acylhydrazone Ligand Bearing Pyrrole Unit

被引：11

作者：

Han Xue-Feng ^{[1
]}

Cai Hong-Xin ^{[2
]}

Jia Lei ^{[2
]}

Wu Wei-Na ^{[2
]}

Zhang Xin ^{[3
]}

Xu Jun ^{[2
]}

Zhang Zhao-Po ^{[2
]}

Wang Yuan ^{[2
]}

机构：

[1] Henan Polytech Univ, Dept Personnel, Jiaozuo 454000, Henan, Peoples R China

[2] Henan Polytech Univ, Dept Chem & Phys, Jiaozuo 454000, Henan, Peoples R China

[3] China Agr Univ, Coll Agr & Biotechnol, Beijing 100083, Peoples R China

来源：

CHINESE JOURNAL OF INORGANIC CHEMISTRY | 2015年 / 31卷 / 07期

关键词：

acylhydrazone; Cu(II) complex; pyrrole; antitumor activity; CU(II) COMPLEXES; ANTIOXIDANT ACTIVITIES; BIOLOGICAL-ACTIVITIES; CRYSTAL-STRUCTURES; 2-ACETYLPYRIDINE; HYDRAZONE; BINDING; NI(II);

D O I：

10.11862/CJIC.2015.188

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two interesting copper(1) complexes,[Cu(H2L)(2)(THF)] (1) and[Cu-2(L)Cl(CH3OH)]center dot H2O (2) based on H3L {ethyl 5-[(2-hydroxy1-4-methylbenzoyDamino-iminomethyl]-3,4-dimethyl-pyrrole-2-carboxylate} were synthesized and characterized by X-ray diffraction analyses. The results show that in complex 1, the copper (11) ion is surrounded by two mono-deprotonated acylhydrazone ligands with NO donor sets and one THF molecule, and thus possesses a distorted square pyramidal geometry. However, in binuclear complex 2, the acylhydrazone ligand is tri-d.eprotonated and bridges two copper(II) ions with square-planar coordination geometry through NO and N2O2 atom sets, respectively. Both complexes have excellent antitumor activities towards A549, ECA109 and SGC7901 cancer cells. CCDC: 1040334, H3L center dot H2O center dot CH3CH2OH; 1040335, 1; 1040336, 2.

引用

页码：1453 / 1459

页数：7

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