Blood pro-inflammatory cytokines in Alzheimer's disease in relation to the use of acetylcholinesterase inhibitors

被引:19
|
作者
Richardson, Cassandra [1 ]
Gard, Paul R. [2 ]
Klugman, Anthony [3 ]
Isaac, Mokhtar [3 ]
Tabet, Naji [3 ,4 ]
机构
[1] Brighton & Sussex Med Sch, Brighton, E Sussex, England
[2] Univ Brighton, Sch Pharm & Biomol Sci, Brighton, E Sussex, England
[3] Sussex Partnership NHS Fdn Trust, Cognit Treatment & Res Unit, St Leonards On Sea, E Sussex, England
[4] Brighton & Sussex Med Sch, Inst Postgrad Med, Brighton, E Sussex, England
关键词
Alzheimer's disease; inflammation; cytokines; acetylcholinesterase inhibitors; cholinergic anti-inflammatory pathway; INTRACEREBROVENTRICULAR INJECTION; CHOLINESTERASE-INHIBITORS; BRAIN-BARRIER; IL-1-BETA; INTERLEUKIN-6; EXPRESSION; SERUM; RECEPTORS; PROTEIN; IL-6;
D O I
10.1002/gps.3966
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
ObjectiveA potential anti-inflammatory role for acetylcholinesterase inhibitors (AChEIs) has been supported by animal studies. As very limited data exist from individuals with Alzheimer's disease (AD), the aim of this study was to assess the potential influence of AChEIs on blood pro-inflammatory cytokines. We hypothesized that pro-inflammatory cytokine concentrations were lower in individuals with AD stabilized on AChEIs. MethodsBlood interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha concentrations were assessed using specific enzyme-linked immunosorbent assays in three groups of participants: patients with AD stabilized on a therapeutic dose of an AChEI (n=42); AChEIs drug naive patients (n=24); and a cognitively unimpaired control group (n=35). Patients in the AChEIs group had received medication for an average of one year. ResultsPatients stabilized on an AChEI did not differ significantly from drug naive patients in relation to the concentrations of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha (p=0.874, 0.225, and 0.978, respectively). Within the group taking AChEIs, the levels of cytokines did not differ between those taking donepezil, rivastigmine, or galantamine (p=0.368, 0.851, and 0.299, respectively). ConclusionsResults from animal studies suggesting a modulatory anti-inflammatory role for AChEIs was not advanced in this study. In individuals with AD, very limited evidence currently exists to support the hypothesis that AChEIs may influence inflammatory blood markers and function beyond the enhancement of neuronal transmission. However, further studies assessing a wider range of inflammatory markers and processes are still needed before this hypothesis can be ruled out. Copyright (c) 2013 John Wiley & Sons, Ltd.
引用
收藏
页码:1312 / 1317
页数:6
相关论文
共 50 条
  • [1] CEREBRAL MTOR SIGNAL AND PRO-INFLAMMATORY CYTOKINES IN ALZHEIMER'S DISEASE RATS
    Wang, Xu
    Li, Guang-Jian
    Hu, Hai-Xia
    Ma, Chi
    Ma, Di-Hui
    Liu, Xiao-Liang
    Jiang, Xiao-Ming
    [J]. TRANSLATIONAL NEUROSCIENCE, 2016, 7 (01) : 151 - 157
  • [2] Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease
    Wang, Wen-Ying
    Tan, Meng-Shan
    Yu, Jin-Tai
    Tan, Lan
    [J]. ANNALS OF TRANSLATIONAL MEDICINE, 2015, 3 (10)
  • [3] Role of Pro-Inflammatory Cytokines and Vitamin D in Probable Alzheimer's Disease with Depression
    Banerjee, Anindita
    Khemka, Vineet Kumar
    Roy, Debashree
    Dhar, Aparajita
    Roy, Tapan Kumar Sinha
    Biswas, Atanu
    Mukhopadhyay, Barun
    Chakrabarti, Sasanka
    [J]. AGING AND DISEASE, 2017, 8 (03): : 267 - 276
  • [4] DNA Methylation Profiles of Selected Pro-Inflammatory Cytokines in Alzheimer Disease
    Nicolia, Vincenzina
    Cavallaro, Rosaria A.
    Lopez-Gonzalez, Irene
    Maccarrone, Mauro
    Scarpa, Sigfrido
    Ferrer, Isidre
    Fuso, Andrea
    [J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2017, 76 (01): : 27 - 31
  • [5] Pro-inflammatory cytokines in inflammatory bowel disease
    McAlindon, ME
    Mahida, YR
    [J]. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 1996, 10 : 72 - 74
  • [6] Treatment with an acetylcholinesterase inhibitor in Alzheimer patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines
    Reale, M
    Iarlori, C
    Gambi, F
    Feliciani, C
    Salone, A
    Toma, L
    DeLuca, G
    Salvatore, M
    Conti, P
    Gambi, D
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2004, 148 (1-2) : 162 - 171
  • [7] Genetic Defects and Pro-inflammatory Cytokines in Parkinson's Disease
    Magnusen, Albert Frank
    Hatton, Shelby Loraine
    Rani, Reena
    Pandey, Manoj Kumar
    [J]. FRONTIERS IN NEUROLOGY, 2021, 12
  • [8] Association of pro-inflammatory cytokines gene polymorphisms with Alzheimer's disease susceptibility in the Han Chinese population
    Yue, Hongmei
    Han, Wei
    Sheng, Li
    [J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (03): : 5422 - +
  • [9] Insulin down regulates the overproduction of pro-inflammatory cytokines in peripheral immune cells in Alzheimer's disease
    Solerte, SB
    Taccani, D
    Locatelli, E
    Ferrari, E
    Fioravanti, M
    [J]. JOURNAL OF NEUROIMMUNOLOGY, 2004, 154 (1-2) : 36 - 36
  • [10] Patients with Alzheimer's disease display a pro-inflammatory phenotype
    Remarque, EJ
    Bollen, ELEM
    Weverling-Rijnsburger, AWE
    Laterveer, JC
    Blauw, GJ
    Westendorp, RGJ
    [J]. EXPERIMENTAL GERONTOLOGY, 2001, 36 (01) : 171 - 176