There are many processing industries that use or produce fragile materials. In recent years, the demand for higher degrees of dust containment, quality control and prevention of inter-batch contamination have compelled these industries to look to pneumatic conveying for their handling needs. However, a paramount concern is that of product degradation and/or generation of dust which can cause direct and indirect material loss and adverse effects on down-stream processes. It is possible to handle most fragile materials with excellent results with today's modem dense-phase systems. This paper will examine the factors which influence industries to select a particular handling method and which pneumatic systems provide for the lowest product degradation.