An Introduction to Normalization and Calibration Methods in Functional MRI

被引：12

作者：

Liu, Thomas T. ^{[1
]}

Glover, Gary H. ^{[2
]}

Mueller, Bryon A. ^{[3
]}

Greve, Douglas N. ^{[4
]}

Brown, Gregory G. ^{[5
,6
]}

机构：

[1] Univ Calif San Diego, Ctr Funct MRI, La Jolla, CA 92093 USA

[2] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[3] Univ Minnesota, Dept Psychiat, Minneapolis, MN 55455 USA

[4] Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02114 USA

[5] VA San Diego Healthcare Syst, San Diego, CA USA

[6] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

来源：

PSYCHOMETRIKA | 2013年 / 78卷 / 02期

关键词：

functional MRI; arterial spin labeling; cerebral blood flow; quantitative fMRI; calibrated fMRI; hypercapnia; CEREBRAL-BLOOD-FLOW; OXYGEN-METABOLISM CHANGES; BOLD-FMRI; NEURAL ACTIVITY; HEMODYNAMIC-RESPONSE; NEURONAL-ACTIVITY; HYPERCAPNIC NORMALIZATION; INDIVIDUAL-DIFFERENCES; OXIDATIVE-METABOLISM; CARBON-DIOXIDE;

D O I：

10.1007/s11336-012-9309-x

中图分类号：

O1 [数学];

学科分类号：

0701 ; 070101 ;

摘要：

In functional magnetic resonance imaging (fMRI), the blood oxygenation level dependent (BOLD) signal is often interpreted as a measure of neural activity. However, because the BOLD signal reflects the complex interplay of neural, vascular, and metabolic processes, such an interpretation is not always valid. There is growing evidence that changes in the baseline neurovascular state can result in significant modulations of the BOLD signal that are independent of changes in neural activity. This paper introduces some of the normalization and calibration methods that have been proposed for making the BOLD signal a more accurate reflection of underlying brain activity for human fMRI studies.

引用

页码：308 / 321

页数：14

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