A collaborative, multidisciplinary approach to HIV transmission risk mitigation during analytic treatment interruption

被引：0
|
作者：
Peluso, Michael J. [1 ]
Dee, Lynda [2 ,3 ,4 ,5 ]
Campbell, Danielle [3 ,4 ,5 ,6 ]
Taylor, Jeff [3 ,5 ,7 ,8 ]
Hoh, Rebecca [1 ]
Rutishauser, Rachel L. [9 ]
Sauceda, John [10 ]
Deeks, Steven G. [1 ]
Dube, Karine [11 ]
机构：
[1] Univ Calif San Francisco, Div HIV Infect Dis & Global Med, San Francisco, CA 94143 USA
[2] AIDS Act Baltimore, Baltimore, MD USA
[3] AmfAR Inst HIV Cure Res, Community Advisory Board, New York, NY USA
[4] Delaney AIDS Res Enterprise, Community Advisory Board, San Francisco, CA USA
[5] Martin Delaney Collaboratory, Community Advisory Board, Bethesda, MD USA
[6] Charles R Drew Univ Med & Sci, 1621 E 120th St, Los Angeles, CA 90059 USA
[7] Univ Calif San Diego, Antiviral Res Ctr, Community Advisory Board, San Diego, CA 92103 USA
[8] HIV Aging Res Project, Palm Springs, CA USA
[9] UCSF, Div Expt Med, San Francisco, CA USA
[10] UCSF, Ctr AIDS Prevent Studies, San Francisco, CA USA
[11] UNC Gillings Sch Global Publ Hlth, Chapel Hill, NC USA
来源：
JOURNAL OF VIRUS ERADICATION | 2020年 / 6卷 / 01期
关键词：
HIV; HIV cure research; HIV remission research; analytical treatment interruption; HETEROSEXUAL TRANSMISSION; ETHICAL CONSIDERATIONS; PREVENTION;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s). Two documented HIV transmissions occurring in the context of ATIs have been recently reported, but recommendations for mitigating the risk of such events during ATIs are limited. We outline a practical approach to risk mitigation during ATI studies and describe strategies we are utilising in an upcoming clinical trial that may be applicable to other centres.
引用
收藏
页码：34 / 37
页数：4
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