Glucocorticoid pharmacogenetics in pediatric idiopathic nephrotic syndrome

被引：15

作者：

Cuzzoni, Eva ^{[1
]}

De Iudicibus, Sara ^{[2
]}

Franca, Raffaella ^{[2
]}

Stocco, Gabriele ^{[3
]}

Lucafo, Marianna ^{[4
]}

Pelin, Marco ^{[3
]}

Favretto, Diego ^{[2
]}

Pasini, Andrea ^{[5
]}

Montini, Giovanni ^{[6
]}

Decorti, Giuliana ^{[3
]}

机构：

[1] Univ Trieste, Grad Sch Reprod & Dev Sci, I-34127 Trieste, Italy

[2] Inst Maternal & Child Hlth IRCCS Burlo Garofolo, I-34137 Trieste, Italy

[3] Univ Trieste, Dept Life Sci, I-34127 Trieste, Italy

[4] Univ Trieste, Dept Med Surg & Hlth Sci, I-34127 Trieste, Italy

[5] Univ St Orsola Malpighi, Azienda Osped, Dept Pediat, Nephrol & Dialysis Unit, I-40138 Bologna, Italy

[6] Univ Milan, Osped Maggiore Policlin, Fdn IRCCS Ca Granda, Dept Clin Sci & Community Hlth,Pediat Nephrol & D, I-20122 Milan, Italy

来源：

PHARMACOGENOMICS | 2015年 / 16卷 / 14期

关键词：

glucocorticoids; glucocorticoid receptor; glucocorticoid receptor heterocomplex; idiopathic nephrotic syndrome; inflammatory mediators; P-gp; polymorphisms; TUMOR-NECROSIS-FACTOR; MIGRATION INHIBITORY FACTOR; FOCAL SEGMENTAL GLOMERULOSCLEROSIS; SINGLE NUCLEOTIDE POLYMORPHISMS; ACUTE LYMPHOBLASTIC-LEUKEMIA; INFLAMMATORY-BOWEL-DISEASE; P-GLYCOPROTEIN EXPRESSION; MDR-1 GENE POLYMORPHISMS; BLOOD MONONUCLEAR-CELLS; BODY-MASS INDEX;

D O I：

10.2217/pgs.15.101

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Idiopathic nephrotic syndrome represents the most common type of primary glomerular disease in children: glucocorticoids (GCs) are the first-line therapy, even if considerable interindividual differences in their efficacy and side effects have been reported. Immunosuppressive and anti-inflammatory effects of these drugs are mainly due to the GC-mediated transcription regulation of pro- and anti-inflammatory genes. This mechanism of action is the result of a complex multistep pathway that involves the glucocorticoid receptor and several other proteins, encoded by polymorphic genes. Aim of this review is to highlight the current knowledge on genetic variants that could affect GC response, particularly focusing on children with idiopathic nephrotic syndrome.

引用

页码：1631 / 1648

页数：18

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