Azole cross-resistance in Aspergillus fumigatus

被引：93
|
作者：
Mosquera, J
Denning, DW
机构：
[1] Wythenshawe Hosp, Educ & Res Ctr, Dept Med, Manchester M29 9LT, Lancs, England
[2] Univ Manchester, Sch Med, Manchester M13 9PT, Lancs, England
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 02期
关键词：
D O I：
10.1128/AAC.46.2.556-557.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We susceptibility tested 17 clinical isolates of Aspergillus fumigates, for most of which MICs of itraeonazole were elevated (MIC at which 50% of the isolates tested are inhibited, 16 mug/ml), against itraconazole, posaconazole, ravuconazole, and voriconazole. Posaconazole was the most active against itraconazole-susceptible isolates. A complex pattern of cross-resistance and hypersusceptibility was seen with voriconazole and ravuconazole, suggesting marked differences in activity and mechanisms of resistance.
引用
收藏
页码：556 / 557
页数：2
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