Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum

被引：19

作者：

Jang, Jun-Pil ^{[1
,2
]}

Nogawa, Toshihiko ^{[3
]}

Futamura, Yushi ^{[3
]}

Shimizu, Takeshi ^{[3
]}

Hashizume, Daisuke ^{[4
]}

Takahashi, Shunji ^{[1
,3
]}

Jang, Jae-Hyuk ^{[2
]}

Ahn, Jong Seog ^{[2
]}

Osada, Hiroyuki ^{[3
]}

机构：

[1] RIKEN Global Res Cluster, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[2] Korea Res Inst Biosci & Biotechnol, Anticanc Agent Res Ctr, Cheongju 28116, South Korea

[3] RIKEN Ctr Sustainable Res Sci, Chem Biol Res Grp, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

[4] RIKEN Ctr Emergent Matter Sci CEMS, Mat Characterizat Support Unit, 2-1 Hirosawa, Wako, Saitama 3510198, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 01期

关键词：

METABOLITE FRACTION LIBRARY; NATURAL-PRODUCTS; MICROBIAL METABOLITES; INHIBITORS; PEPTIDES;

D O I：

10.1021/acs.jnatprod.6b00758

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new cyclic octadepsipeptides, octaminomycins A (1) and B (2), were isolated from a microbial metabolite fraction library of Streptomyces sp. RK85-270 based on Natural Products Plot screening. Their structures were elucidated on the basis of HRESIMS, 1D and 2D NMR spectroscopic data, and MS/MS experiments for sequence analysis. The absolute configurations of the constituent amino acid residues were determined by a combination of single crystal X-ray diffraction and Marfey's methodology. Notably, octaminomycins A (1) and B (2) showed good in vitro antiplasmodial activity against chloroquine-sensitive as well as chloroquine-resistant strains with no cytotoxicity up to 30 mu M.

引用

页码：134 / 140

页数：7

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