Effect of compounds isolated from natural products on IFN-γ/LPS-Induced nitric oxide production in RAW 264.7 macrophages

被引：14
|
作者：
Syahida, A
Israf, DA [1 ]
Lajis, NH
Khozirah, S
Habsah, M
Jasril
Permana, D
Norhadiani, I
机构：
[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Serdang 43400, Selangor, Malaysia
[2] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Selangor, Malaysia
[3] Univ Putra Malaysia, Fac Sci, Serdang 43400, Selangor, Malaysia
来源：
PHARMACEUTICAL BIOLOGY | 2006年 / 44卷 / 01期
关键词：
macrophages; nitric oxide; phytochemicals;
D O I：
10.1080/13880200500530765
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The current study was designed to evaluate whether compounds isolated from local medicinal plants in Malaysia suppressed nitric oxide (NO) production in inflammation. The murine monocytic macrophage (RAW 264.7) cell line was used as a target cell and activated by interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Our current study has identified four phytochemicals, namely atrovirinone, cardamonin, flavokawin B, and zerumbone, that inhibit pathological NO generation. These compounds are candidates for further bioassay studies to determine their suitability as drug leads.
引用
收藏
页码：50 / 59
页数：10
相关论文
共 50 条
  • [1] Ovalbumin Hydrolysates Inhibit Nitric Oxide Production in LPS-induced RAW 264.7 Macrophages
    Kim, Hyun Suk
    Lee, Jae Hoon
    Moon, Sun Hee
    Ahn, Dong Uk
    Paik, Hyun-Dong
    [J]. FOOD SCIENCE OF ANIMAL RESOURCES, 2020, 40 (02) : 274 - 285
  • [2] Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-γ-activated RAW 264.7 macrophages
    Wang, J
    Mazza, G
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (04) : 850 - 857
  • [3] Effect of lactic acidosis on LPS-induced production of inflammatory cytokines and nitric oxide in raw 264.7 macrophages
    Song, MC
    Kellum, JA
    [J]. CRITICAL CARE MEDICINE, 2002, 30 (12) : A54 - A54
  • [4] Stimulus (polyphenol, IFN-γ, LPS)-dependent nitric oxide production and antileishmanial effects in RAW 264.7 macrophages
    Kolodziej, Herbert
    Radtke, Oliver A.
    Kiderlen, Albrecht F.
    [J]. PHYTOCHEMISTRY, 2008, 69 (18) : 3103 - 3110
  • [5] Effects of indole α-lipoic acid derivatives on nitric oxide production in LPS/IFN-γ activated RAW 264.7 macrophages
    Karabay, A. Z.
    Koc, A.
    Gurkan, S.
    Buyukbingol, Z.
    Buyukbingol, E.
    [J]. FEBS JOURNAL, 2014, 281 : 120 - 120
  • [6] Nitric oxide-scavenging compounds in Agrimonia pilosa Ledeb on LPS-induced RAW264.7 macrophages
    Taira, Junsei
    Nanbu, Hitoshi
    Ueda, Katsuhiro
    [J]. FOOD CHEMISTRY, 2009, 115 (04) : 1221 - 1227
  • [7] Tetracyclines tigecycline and doxycycline inhibit LPS-induced nitric oxide production by RAW 264.7 murine macrophages.
    Kaushik, Vidhu
    Beduya, Dino
    Kalampokis, Loannis
    Kohlhoff, Stephan
    Joks, Rauno O.
    Durkin, Helen G.
    Nowakowski, Maja
    [J]. JOURNAL OF IMMUNOLOGY, 2007, 178
  • [8] Effects of florfenicol on LPS-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages
    Zhang, Xuemei
    Xiong, Huanzhang
    Li, Hongyu
    Yu, Lu
    Deng, Xuming
    [J]. FUNDAMENTAL & CLINICAL PHARMACOLOGY, 2011, 25 (05) : 591 - 598
  • [9] The effect of linarin on LPS-induced cytokine production and nitric oxide inhibition in murine macrophages cell line RAW264.7
    Han, S
    Sung, KH
    Yim, D
    Lee, S
    Lee, CK
    Ha, NJ
    Kim, K
    [J]. ARCHIVES OF PHARMACAL RESEARCH, 2002, 25 (02) : 170 - 177
  • [10] Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages
    Dirsch, VM
    Stuppner, H
    Ellmerer-Müller, EP
    Vollmar, AM
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2000, 8 (12) : 2747 - 2753
12345