Relay photocatalytic cascade reactions: synthesis of indolo[2,1-a] isoquinoline derivatives via double C(sp3)-H bond functionalization

被引：18
|
作者：
Cheng, Jian [1 ]
Xie, Jin [1 ]
Zhu, Chengjian [1 ,2 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Adv Organ Mat, State Key Lab Coordinat Chem, Nanjing 210023, Jiangsu, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 13期
基金：
中国国家自然科学基金;
关键词：
LIGHT PHOTOREDOX CATALYSIS; VISIBLE-LIGHT; ALKENES; TRIFLUOROMETHYLATION; CYCLOPROPANATION; DISCOVERY; RADICALS; STRATEGY;
D O I：
10.1039/c7cc09820k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A relay photoredox catalysis strategy concomitant with [1,5] hydrogen atom transfer has been applied in the construction of a biologically important indolo[2,1-a] isoquinoline framework via a cascade reaction. This reaction enables double C(sp(3))-H bond functionalization and formation of two carbon-carbon double bonds from readily available starting materials in an efficient and step-economical manner.
引用
收藏
页码：1655 / 1658
页数：4
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