Platinum(IV) Complexes Featuring One or Two Axial Ferrocene Bearing Ligands - Synthesis, Characterization, and Cytotoxicity

被引：32

作者：

Banfic, Jelena ^{[1
]}

Legin, Anton A. ^{[1
]}

Jakupec, Michael A. ^{[1
]}

Galanski, Markus ^{[1
]}

Keppler, Bernhard K. ^{[1
,2
]}

机构：

[1] Univ Vienna, Inst Inorgan Chem, A-1090 Vienna, Austria

[2] Univ Vienna, Res Platform Translat Canc Therapy Res, A-1090 Vienna, Austria

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2014年 / 2014卷 / 03期

关键词：

Platinum; Ferrocene; Antitumor agents; Cytotoxicity; Metallocenes;

D O I：

10.1002/ejic.201301282

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Ferrocenyl compounds show interesting antiproliferative properties. Consequently, ferrocene bearing moieties were prepared and coupled for the first time to anticancer platinum(IV) complexes. The compounds, featuring either one or two axially coordinated ferrocene-containing ligands, were fully characterized by ESI-MS and multinuclear (H-1, C-13, N-15, and Pt-195) one- and two-dimensional NMR spectroscopy. Their cytotoxicity was investigated in three human cancer cell lines deriving from ovarian carcinoma (CH1), colon carcinoma (SW480), and non-small-cell lung carcinoma (A549) by means of the colorimetric MTT assay. Promising IC50 values in the low micromolar range in CH1 and SW480 human cancer cells were found.

引用

页码：484 / 492

页数：9

共 50 条

[1] Platinum(IV) Complexes Featuring Axial Michael Acceptor Ligands - Synthesis, Characterization, and Cytotoxicity
Sommerfeld, Nadine S.
Strohhofer, Daniel
Cseh, Klaudia
Theiner, Sarah
Jakupec, Michael A.
Koellensperger, Gunda
Galanski, Markus
Keppler, Bernhard K.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2017, (34) : 4049 - 4054
[2] Synthesis, characterization and cytotoxicity of mono- and dicarboxylated platinum(IV) compounds featuring ferrocene-ligands
Banfic, J.
Galanski, M.
Jakupec, M. A.
Keppler, B. K.
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2014, 19 : S626 - S626
[3] Synthesis, structure, and cytotoxicity of platinum(iv) complexes bearing aminoxyl and dichloroacetate ligands
Sen, V. D.
Filatova, N. V.
Shilov, G. V.
Terentiev, A. A.
RUSSIAN CHEMICAL BULLETIN, 2023, 72 (07) : 1680 - 1687
[4] Synthesis, structure, and cytotoxicity of platinum(iv) complexes bearing aminoxyl and dichloroacetate ligands
V. D. Sen’
N. V. Filatova
G. V. Shilov
A. A. Terentiev
Russian Chemical Bulletin, 2023, 72 : 1680 - 1687
[5] Bis- and Tetrakis(carboxylato)platinum(IV) Complexes with Mixed Axial Ligands - Synthesis, Characterization, and Cytotoxicity
Hoffmeister, Bjoern R.
Hejl, Michaela
Adib-Razavi, Mahsa S.
Jakupec, Michael A.
Galanski, Markus
Keppler, Bernhard K.
CHEMISTRY & BIODIVERSITY, 2015, 12 (04) : 559 - 574
[6] Synthesis, characterization and in vitro cytotoxicity studies of platinum(IV) complexes with thiouracil ligands
Vetter, Cornelia
Kaluderovic, Goran N.
Paschke, Reinhard
Kluge, Ralph
Schmidt, Juergen
Steinborn, Dirk
INORGANICA CHIMICA ACTA, 2010, 363 (11) : 2452 - 2460
[7] Synthesis, Characterization, and Cytotoxicity of Platinum(IV) Carbamate Complexes
Wilson, Justin J.
Lippard, Stephen J.
INORGANIC CHEMISTRY, 2011, 50 (07) : 3103 - 3115
[8] Synthesis, Characterization, and In Vitro Cytotoxicity of Platinum(II) Complexes Bearing Chiral Tetradentate Salicylaldimine Ligands
Nguyen, Quang Trung
Pham Thi, Phuong Nam
Nguyen, Van Tuyen
JOURNAL OF CHEMISTRY, 2020, 2020
[9] Synthesis, characterization, cytotoxicity, and DNA binding of some new platinum(II) and platinum(IV) complexes with benzimidazole ligands
Utku, Semra
Gumus, Fatma
Tezcan, Seda
Serin, Mehmet Sami
Ozkul, Aykut
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2010, 25 (04) : 502 - 508
[10] Synthesis and characterization of platinum (II) and platinum (IV) complexes with pincer ligands
Zhao, Daoli
Krause, Jeanette A.
Connick, William B.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2009, 238

← 1 2 3 4 5 →