Regulation of insulin-induced tyrosine-phosphorylation of IRS-1, IRS-2, and IRS-3 in adipose tissue of two distinct animal models of insulin resistance:: Aging and glucocoticoid excess in vivo

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Caperuto, LC
Souza, LC
Anhe, GF
Campbell, C
Carvalho, CO
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R5 [内科学];
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1002 ; 100201 ;
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页码:A291 / A291
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  • [1] Distinct roles of IRS-1 and IRS-2 in insulin-induced gene transcription in hepatocytes
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    Ogawa, W
    Sakaue, H
    Kasuga, M
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  • [2] IRS-2 differs from IRS-1 in insulin-induced tyrosine phosphorylation and activation of PI 3-kinase.
    Ogihara, T
    Funaki, M
    Katagiri, H
    Oka, Y
    Yazaki, Y
    Asano, T
    DIABETES, 1996, 45 : 435 - 435
  • [3] Gene expression explains IRS-2, but not IRS-1, depletion in glucose- and insulin-induced insulin resistance
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  • [4] IRS-1 but not IRS-2 differentially modulates insulin-stimulated tyrosine phosphorylation of the insulin receptor
    Jarett, L
    Solow, BT
    Harada, S
    Smith, JA
    Goldstein, BJ
    DIABETES, 1999, 48 : A338 - A338
  • [5] Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2
    Kido, Y
    Burks, DJ
    Withers, D
    Bruning, JC
    Kahn, CR
    White, MF
    Accili, D
    JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (02): : 199 - 205
  • [6] Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    Paz, K
    Hemi, R
    LeRoith, D
    Karasik, A
    Elhanany, E
    Kanety, H
    Zick, Y
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (47) : 29911 - 29918
  • [7] Glucose- and insulin-induced phosphorylation of the insulin receptor and its primary substrates IRS-1 and IRS-2 in rat pancreatic islets
    Velloso, LA
    Carneiro, EM
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  • [8] Different subcellular distribution and regulation of expression of insulin receptor substrate (IRS)-3 from those of IRS-1 and IRS-2
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    Onishi, Y
    Yazaki, Y
    Kikuchi, M
    Oka, Y
    Asano, T
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (45) : 29686 - 29692
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