Synthesis and Bioactivities of Novel Pyrazole Oxime Ethers Containing Substituted Pyrazolyl Group

In order to find novel pyrazole oxime ethers with good bioactivities, a series of novel pyrazole oxime ether compounds containing substituted pyrazole moiety were designed and synthesized according to the method of active substructure combination. Their structures were characterized by H-1 NMR, C-13 NMR, and elemental analysis. Preliminary bioassay displayed that most target compounds had good insecticidal activities. At the concentration of 500 mu g/mL, sixteen compounds showed insecticidal activity against Oriental armyworm with 80%similar to 100%, fourteen compounds exhibited insecticidal activity against Aphis medicaginis with 80%similar to 100%, and twelve compounds showed insecticidal activity against Nilaparvata lugens with 70%similar to 100%. When the dosage was lowered to 100 mu g/mL, five compounds still possessed inhibitory effect against Aphis medicaginis with 50%similar to 80%.