Lignans from Opuntia ficus-indica seeds protect rat primary hepatocytes and HepG2 cells against ethanol-induced oxidative stress

被引：17

作者：

Kim, Jung Wha ^{[1
,2
]}

Yang, Heejung ^{[3
]}

Kim, Hyeon Woo ^{[1
,2
]}

Kim, Hong Pyo ^{[4
]}

Sung, Sang Hyun ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul, South Korea

[2] Seoul Natl Univ, Pharmaceut Sci Res Inst, Seoul, South Korea

[3] Kangwon Natl Univ, Coll Pharm, Chunchon, South Korea

[4] Ajou Univ, Coll Pharm, Suwon, South Korea

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2017年 / 81卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Opuntia ficus-indica; lignin; hepatoprotective activity; heme oxygenase-1; VAR; SABOTEN; FRUIT JUICE; MORINDA-CITRIFOLIA; CONSTITUENTS; ANTIOXIDANT;

D O I：

10.1080/09168451.2016.1234930

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioactivity-guided isolation of Opuntia ficus-indica (Cactaceae) seeds against ethanol-treated primary rat hepatocytes yielded six lignan compounds. Among the isolates, furofuran lignans 4-6, significantly protected rat hepatocytes against ethanol-induced oxidative stress by reducing intracellular reactive oxygen species levels, preserving antioxidative defense enzyme activities, and maintaining the glutathione content. Moreover, 4 dose-dependently induced the heme oxygenase-1 expression in HepG2 cells.

引用

页码：181 / 183

页数：3

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