Rationale for combining PARP inhibitors with topotecan or irinotecan: taking advantage of the alternative DNA repair pathways involving XPF-ERCC1 and PARP-TDP1

被引:0
|
作者
Zhang, Yongwei [1 ]
Regairaz, Marie [1 ]
Seiler, Jennifer [1 ]
Agama, Keli [1 ]
Doroshow, James [1 ]
Pommier, Yves [1 ]
机构
[1] NCI, Bethesda, MD 20892 USA
关键词
D O I
10.1158/1538-7445.AM2012-4691
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
4691
引用
收藏
页数:2
相关论文
共 3 条
  • [1] Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
    Thomas, Adam M.
    Brolih, Sanja
    McGouran, Joanna F.
    El-Sagheer, Afaf H.
    Ptchelkine, Denis
    Jones, Morgan
    McDonald, Neil Q.
    McHugh, Peter J.
    Brown, Tom
    CHEMICAL COMMUNICATIONS, 2019, 55 (78) : 11671 - 11674
  • [2] Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cells
    Zhang, Yong-Wei
    Regairaz, Marie
    Seiler, Jennifer A.
    Agama, Keli K.
    Doroshow, James H.
    Pommier, Yves
    NUCLEIC ACIDS RESEARCH, 2011, 39 (09) : 3607 - 3620
  • [3] Targeting Replicative Stress and DNA Repair by Combining PARP and Wee1 Kinase Inhibitors Is Synergistic in Triple Negative Breast Cancers with Cyclin E or BRCA1 Alteration
    Chen, Xian
    Yang, Dong
    Carey, Jason P. W.
    Karakas, Cansu
    Albarracin, Constance
    Sahin, Aysegul A.
    Arun, Banu K.
    Guray Durak, Merih
    Li, Mi
    Kohansal, Mehrnoosh
    Bui, Tuyen N.
    Ha, Min-Jin
    Hunt, Kelly K.
    Keyomarsi, Khandan
    CANCERS, 2021, 13 (07)