Total Synthesis of (±)-Calcaridine A and (±)-epi-Calcaridine A

被引：28

作者：

Koswatta, Panduka B. ^{[1
]}

Sivappa, Rasapalli ^{[1
]}

Dias, H. V. Rasika ^{[1
]}

Lovely, Carl J. ^{[1
]}

机构：

[1] Univ Texas Arlington, Dept Chem & Biochem, Arlington, TX 76019 USA

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 21期

关键词：

D O I：

10.1021/ol802018r

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of the Leucetta alkaloid calcaridine A is described based on a biosynthetic postulate. Application of an oxidative rearrangement of a 4,5-disubstituted imidazole leads to the formation of both calcaridine A and epi-calcaridine A. An X-ray crystal structure determination on the latter has allowed the assignment of the relative configuration of the epimeric natural product and calcaridine A by extrapolation.

引用

页码：5055 / 5058

页数：4

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