Genetic Interaction of APOE and FGF1 is Associated with Memory Impairment and Hippocampal Atrophy in Alzheimer's Disease

被引:9
|
作者
Chang, Ya-Ting [1 ]
Kazui, Hiroaki [2 ]
Ikeda, Manabu [2 ]
Huang, Chi-Wei [1 ]
Huang, Shu-Hua [3 ]
Hsu, Shih-Wei [4 ]
Chang, Wen-Neng [1 ]
Chang, Chiung-Chih [1 ]
机构
[1] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Neurol, Coll Med, Kaohsiung 83301, Taiwan
[2] Osaka Univ, Dept Psychiat, Grad Sch Med, Suita, Osaka 5650871, Japan
[3] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Nucl Med, Coll Med, Kaohsiung 83301, Taiwan
[4] Chang Gung Univ, Kaohsiung Chang Gung Mem Hosp, Dept Radiol, Coll Med, Kaohsiung 83301, Taiwan
来源
AGING AND DISEASE | 2019年 / 10卷 / 03期
关键词
APOE; episodic memory; FGF1; genetic interaction; hippocampus; FIBROBLAST-GROWTH-FACTOR; GENOME-WIDE ASSOCIATION; APOLIPOPROTEIN-E; FIBROBLAST-GROWTH-FACTOR-1; GENE; NETWORK CONNECTIVITY; IDENTIFIES VARIANTS; BRAIN; EPSILON-4; LOBE; POLYMORPHISM;
D O I
10.14336/AD.2018.0606
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The APOE and fibroblast growth factor 1 (FGF1) have both been associated with amyloid beta accumulation and neurodegeneration. Investigation the effect of APOE-FGF1 interactions on episodic memory (EM) deficits and hippocampus atrophy (HA) might elucidate the complex clinical-pathological relationship in Alzheimer's disease (AD). EM performance and hippocampal volume (HV) were characterized in patients with mild AD based on APOE-epsilon 4 carrier status (APOE-epsilon 4 carriers versus non-carriers) and FGF1 single nucleotide polymorphism (FGF1-rs34011-GG versus FGF1-rs34011-A-allele carriers). The clinical-pathological relationships within each genotypic group (epsilon 4+/GG-carrier, epsilon 4+/A-allele-carrier, epsilon 4-/GG-carrier, and epsilon 4-/A-allele-carrier) were analyzed. There were no significant differences between the FGF1-rs34011-GG and FGF1-rs34011-A-allele carriers for the level of EM performance or HV (p> 0.05). The bilateral HV was significantly smaller and EM impairment was significantly worse in epsilon 4+/GG-carrier than in epsilon 4-/A-allele-carrier, and an interaction effect of APOE (APOE-epsilon 4 carriers versus non-carriers) with FGF1 (FGF1-rs34011-GG versus FGF1-rs34011-A-allele carriers) predicted EM impairment (F4,92= 3.516, p= 0.018) and structural changes in voxel-based morphometry. Our data shows that concurrent consideration of APOE and FGF1 poly morphisms might be required to understand the clinical-pathological relationship in AD.
引用
收藏
页码:510 / 519
页数:10
相关论文
共 50 条
  • [1] Genetic interaction of PICALM and APOE is associated with brain atrophy and cognitive impairment in Alzheimer's disease
    Morgen, Katrin
    Ramirez, Alfredo
    Froelich, Lutz
    Tost, Heike
    Plichta, Michael M.
    Koelsch, Heike
    Rakebrandt, Fabian
    Rienhoff, Otto
    Jessen, Frank
    Peters, Oliver
    Jahn, Holger
    Luckhaus, Christian
    Huell, Michael
    Gertz, Hermann-Josef
    Schroeder, Johannes
    Hampel, Harald
    Teipel, Stefan J.
    Pantel, Johannes
    Heuser, Isabella
    Wiltfang, Jens
    Ruether, Eckart
    Kornhuber, Johannes
    Maier, Wolfgang
    Meyer-Lindenberg, Andreas
    [J]. ALZHEIMERS & DEMENTIA, 2014, 10 (05) : S269 - S276
  • [2] APOE4 is associated with greater atrophy of the hippocampal formation in Alzheimer's disease
    Pievani, Michela
    Galluzzi, Samantha
    Thompson, Paul M.
    Rasser, Paul E.
    Bonetti, Matteo
    Frisoni, Giovanni B.
    [J]. NEUROIMAGE, 2011, 55 (03) : 909 - 919
  • [3] A Variant Within FGF1 is Associated With Alzheimer's Disease in the Han Chinese Population
    Tao, Qing-Qing
    Sun, Yi-Min
    Liu, Zhi-Jun
    Ni, Wang
    Yang, Ping
    Li, Hong-Lei
    Lu, Shen-Ji
    Wu, Zhi-Ying
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2014, 165 (02) : 131 - 136
  • [4] APOE4 Genotype Is Associated with Greater Atrophy of the Hippocampal Formation in Alzheimer's Disease
    Pievani, Michela
    Galluzzi, Samantha
    Thompson, Paul
    Rasser, Paul E.
    Bonetti, Matteo
    Frisoni, Giovanni
    [J]. NEUROLOGY, 2011, 76 (09) : A300 - A300
  • [5] Genetic interaction is associated with lower metabolic connectivity and memory impairment in clinically mild Alzheimer's disease
    Chang, Y. -T.
    Huang, C. -W.
    Huang, S. -H.
    Hsu, S. -W.
    Chang, W. -N.
    Lee, J. -J.
    Chang, C. -C.
    [J]. GENES BRAIN AND BEHAVIOR, 2019, 18 (05)
  • [6] Mapping Hippocampal Atrophy in Mild Cognitive Impairment and Alzheimer's Disease
    Apostolova, Liana G.
    Green, Amity E.
    Hwang, Kristy S.
    Cummings, Jeffrey L.
    Toga, Arthur W.
    Thompson, Paul M.
    [J]. NEUROLOGY, 2009, 72 (11) : A96 - A96
  • [7] Hippocampal Atrophy Patterns in Mild Cognitive Impairment and Alzheimer's Disease
    Mueller, Susanne G.
    Schuff, Norbert
    Yaffe, Kristine
    Madison, Catherine
    Miller, Bruce
    Weiner, Michael W.
    [J]. HUMAN BRAIN MAPPING, 2010, 31 (09) : 1339 - 1347
  • [8] Cognitive Impairment Associated with APOE Biomarkers in Alzheimer's Disease
    Diah, K.
    Vitale, G.
    Keith, M.
    Fornalski, N.
    Golden, C.
    [J]. ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2017, 32 (06) : 668 - 668
  • [9] Hippocampal atrophy in Alzheimer's disease
    OBrien, JT
    [J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 1996, 11 (01) : 83 - 83
  • [10] Hippocampal atrophy in Alzheimer's disease
    Soininen, Hilkka
    Liu, Yawu
    Rueckert, Daniel
    Lotjonen, Jyrki
    [J]. NEURODEGENERATIVE DISEASE MANAGEMENT, 2012, 2 (02) : 197 - 209