The expression of fractalkine in the endometrium during the menstrual cycle

被引：10
|
作者：
Watanabe, M [1 ]
Shimoya, K [1 ]
Zhang, Q [1 ]
Temma-Asano, K [1 ]
Kimura, T [1 ]
Murata, Y [1 ]
机构：
[1] Osaka Univ, Grad Sch Med, Dept Obstet & Gynecol, Osaka, Japan
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS | 2006年 / 92卷 / 03期
关键词：
fractalkine; endometrium; CX(3)CR1; menstruation;
D O I：
10.1016/j.ijgo.2005.12.012
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: The objective of the study was to evaluate the presence of fractalkine in the endometrium of the uterus and the change of fractalkine protein levels during menstrual cycle. Methods: Twelve samples of endometrium of the uterus were obtained from gynecological patients who underwent total hysterectomy. Western blotting, RT-PCR and immunohistochemistry were performed. Results: Fractalkine protein was detected in the endometrium of the uterus. Positive staining was confirmed in the epithelial. cells and grandular cells in the endometrium. Expression levels of fractalkine protein and mRNA in the endometrium during secretory phase were significantly higher than those during proliferative phase. Immunohistochemical analysis using an anti-CX(3)CR1 antibody demonstrated positive staining in the glandular cells of the endometrium of the uterus. Conclusion: Fractalkine was expressed in the endometrium and its production was up-regulated during secretory phase. (c) 2005 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：242 / 247
页数：6
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