A mathematical model of Schistosoma mansoni in Biomphalaria glabrata with control strategies

被引:11
|
作者
Zhao, Ruijun [1 ]
Milner, Fabio Augusto [1 ]
机构
[1] Purdue Univ, Dept Math, W Lafayette, IN 47907 USA
关键词
schistosomiasis; castration; chemoprophylaxis; logistic growth;
D O I
10.1007/s11538-008-9330-5
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We describe and analyze a mathematical model for schistosomiasis in which infected snails are distinguished from susceptible through increased mortality and no reproduction. We based the model on the same derivation as Anderson and May (J. Anim. Ecol. 47:219-247, 1978), Feng and Milner (A New Mathematical Model of Schistosomiasis, Mathematical Models in Medical and Health Science, Nashville, TN, 1997. Innov. Appl. Math., Vanderbilt Univ. Press, Nashville, pp. 117-128, 1998), and May and Anderson (J. Anim. Ecol. 47:249-267, 1978), but used logistic growth both in human and snail hosts. We introduce a parameter r, the effective coverage of medical treatment/prevention to control the infection. We determine a reproductive number for the disease directly related to its persistence and extinction. Finally, we obtain a critical value for r that indicates the minimum treatment effort needed in order to clear out the disease from the population.
引用
收藏
页码:1886 / 1905
页数:20
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