Discovery of Small-Molecule Inhibitors of the TLR1/TLR2 Complex

被引:131
|
作者
Cheng, Kui [1 ,2 ]
Wang, Xiaohui [1 ,2 ]
Zhang, Shuting [1 ,2 ]
Yin, Hang [1 ,2 ]
机构
[1] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
[2] Univ Colorado, BioFrontiers Inst, Boulder, CO 80309 USA
基金
美国国家卫生研究院;
关键词
drug discovery; inhibitors; innate immunity; Toll-like receptors; TOLL-LIKE RECEPTORS; STAPHYLOCOCCUS-AUREUS; INNATE IMMUNITY; RECOGNITION; SPECIFICITY; POLYPHENOLS; ANTAGONIST; PROTEINS; BINDING; CANCER;
D O I
10.1002/anie.201204910
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:12246 / 12249
页数:4
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