Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water

被引：58
|
作者：
Staudt, Svenja [1 ]
Burda, Edyta [1 ]
Giese, Carolin [2 ]
Mueller, Christina A. [3 ]
Marienhagen, Jan [3 ]
Schwaneberg, Ulrich [3 ]
Hummel, Werner [4 ]
Drauz, Karlheinz [5 ]
Groeger, Harald [1 ,2 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91054 Erlangen, Germany
[2] Univ Bielefeld, Fac Chem, D-33615 Bielefeld, Germany
[3] Rhein Westfal TH Aachen, Inst Biotechnol, D-52074 Aachen, Germany
[4] Univ Dusseldorf, Res Ctr Julich, Inst Mol Enzyme Technol, D-52426 Julich, Germany
[5] Evonik Degussa GmbH, Int Sci Relat, Innovat Management Chem, D-63457 Hanau, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 08期
关键词：
alkanes; enzyme catalysis; ketones; oxidation; ALCOHOL-DEHYDROGENASE; HYDROXYLATION; P450BM-3; MONOOXYGENASES; F87V;
D O I：
10.1002/anie.201204464
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP+ (and a little 2-propanol to reduce it), as well as two catalytic enzymes - a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme). Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：2359 / 2363
页数：5
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