Pre-operative chemo-radiotherapy improves the sphincter preservation rate in patients with rectal cancer located within 3 cm of the anal verge

被引：35
|
作者：
Kim, DW [1 ]
Lim, SB [1 ]
Kim, DY [1 ]
Kim, TH [1 ]
Jung, KH [1 ]
Kim, DH [1 ]
Chang, HJ [1 ]
Sohn, DK [1 ]
Hong, CW [1 ]
Choi, HS [1 ]
Jeong, SY [1 ]
Park, JG [1 ]
机构：
[1] Natl Canc Ctr, Res Inst Hosp, Ctr Colorectal Canc, Goyang 411769, Gyeonggi, South Korea
来源：
EJSO | 2006年 / 32卷 / 02期
关键词：
rectal cancer; sphincter preservation; pre-operative chemo-radiotherapy; ultralow anterior resection; transanal excision;
D O I：
10.1016/j.ejso.2005.10.002
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aims: To evaluate whether pre-operative chemo-radiotherapy (CRT) improves the sphincter preservation rate for distal rectal cancers within 3 cm of the anal verge. Methods: Between January 2001 and December 2004, 49 patients underwent surgery with or without pre-operative CRT for primary rectal adenocarcinoma within 3 cm of the anal verge. Clinical data were retrospectively reviewed, including stage workups, surgical records and pathology records to determine sphincter preservation rate and the factors influencing sphincter preservation. Results: Of 49 patients with rectal tumours within 3 cm of the anal verge, 31 underwent pre-operative CRT followed by surgery (CRT group), and 18 underwent surgery alone (non-CRT group). Sphincter preservation was possible in I I of 31 CRT patients, and only one of 18 non-CRT patients (p = 0.036). The factors most influencing sphincter preservation were reduction in tumour size (p = 0.005) and downstaging (p=0.001) following pre-operative CRT. Conclusion: We could observe that sphincter preservation was improved in CRT group with statistical significance when compared to non-CRT group in our study patients with rectal cancer within 3 cm, of the anal verge. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：162 / 167
页数：6
相关论文
共 50 条
  • [1] Chemo-radiotherapy versus radiotherapy alone in the pre-operative treatment of resectable rectal cancer
    Goethals, L
    Haustermans, K
    Perneel, C
    Bussels, B
    D'Hoore, A
    Geboes, K
    Ectors, N
    Van Cutsem, E
    Van den Bogaert, W
    Penninckx, F
    [J]. EJSO, 2005, 31 (09): : 969 - 976
  • [2] Radiation dose intensification in pre-operative chemo-radiotherapy for locally advanced rectal cancer
    F. Alongi
    S. Fersino
    R. Mazzola
    A. Fiorentino
    N. Giaj-Levra
    F. Ricchetti
    R. Ruggieri
    G. Di Paola
    M. Cirillo
    S. Gori
    M. Salgarello
    G. Zamboni
    G. Ruffo
    [J]. Clinical and Translational Oncology, 2017, 19 : 189 - 196
  • [3] Radiation dose intensification in pre-operative chemo-radiotherapy for locally advanced rectal cancer
    Alongi, F.
    Fersino, S.
    Mazzola, R.
    Fiorentino, A.
    Giaj-Levra, N.
    Ricchetti, F.
    Ruggieri, R.
    Di Paola, G.
    Cirillo, M.
    Gori, S.
    Salgarello, M.
    Zamboni, G.
    Ruffo, G.
    [J]. CLINICAL & TRANSLATIONAL ONCOLOGY, 2017, 19 (02): : 189 - 196
  • [4] PROGNOSTIC VALUE OF TOTAL TUMOR REGRESSION AFTER PRE-OPERATIVE CHEMO-RADIOTHERAPY IN RECTAL CANCER (RC)
    Gavioli, Margherita
    Luppi, Gabriele
    Losi, Lorena
    Bertolini, Federica
    Giacobazzi, Patrizia
    Zironi, Sandra
    Natalini, Gianni
    Bertoni, Filippo
    Conte, Pier Franco
    [J]. ANNALS OF ONCOLOGY, 2004, 15 : 58 - 59
  • [5] Manometric Evaluation of Anorectal Function in Patients Treated With Pre-Operative Chemo-Radiotherapy and Total Mesorectal Excision for Rectal Cancer
    Corsetti, Maura
    Giollo, Patrizia
    Testoni, Sabrina G.
    Andreoletti, Hulda
    De Nardi, Paola
    Mezzi, Gianni
    Passaretti, Sandro M.
    Arcidiacono, Paolo G.
    Testoni, Pier Alberto
    [J]. GASTROENTEROLOGY, 2012, 142 (05) : S899 - S899
  • [6] Long term outcomes following long course pre-operative chemo-radiotherapy for locally advanced rectal cancer
    Battula, N.
    Laird, S.
    Mathew, G.
    Marimuthu, K.
    Jadhav, V.
    [J]. BRITISH JOURNAL OF SURGERY, 2011, 98 : 88 - 88
  • [7] ONCOLOGICAL OUTCOME FOLLOWING 'WATCH AND WAIT' FOR CLINICAL COMPLETE RESPONSE AFTER PRE-OPERATIVE CHEMO-RADIOTHERAPY IN PATIENTS WITH RECTAL CANCER
    Renehan, A.
    Malcomson, L.
    Emsley, R.
    Gollins, S.
    Scott, N.
    O'Dwyer, S. T.
    [J]. GUT, 2015, 64 : A3 - A3
  • [8] Disparities in the use of Pre-Operative Radiation and Sphincter Preservation among California Rectal Cancer Patients
    Chae, A. W.
    Yang, A. D.
    Canter, R. J.
    Bold, R. J.
    Khatri, V. P.
    Martinez, S. R.
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2013, 20 : S75 - S75
  • [9] UTILITY OF MAGNETIC RESONANCE IMAGING FOLLOWING LONG-COURSE PRE-OPERATIVE CHEMO-RADIOTHERAPY FOR LOCALLY ADVANCED RECTAL CANCER
    Lucey, D. J.
    Murphy, A.
    Curran, V.
    McCourt, M.
    Andrews, E.
    O'Riordain, M.
    Power, D. G.
    O'Reilly, S.
    Kelly, P. J.
    [J]. ANNALS OF ONCOLOGY, 2012, 23 : 207 - 207
  • [10] MTHFR, TSER and DPYD gene mutation is associated with toxicity and response in pre-operative chemo-radiotherapy for local advanced rectal cancer
    De Giorgi, D.
    Poti, O.
    Schirinzi, M. L.
    De Maria, G.
    Galante, M. M.
    Mancarella, S.
    [J]. ANNALS OF ONCOLOGY, 2017, 28
12345