Is there still a role for autologous stem cell transplantation in acute myeloid leukemia?

被引:2
|
作者
Al Sabty, F. [1 ]
Demeckova, E. [1 ]
Bojtarova, E. [1 ]
Hrubisko, M. [2 ]
Mistrik, M. [3 ]
机构
[1] Univ Hosp, Dept Hematol & Transfus Med, Bratislava, Slovakia
[2] Slovak Med Univ, Bratislava, Slovakia
[3] Comenius Univ, Bratislava, Slovakia
关键词
acute myeloid leukemia; autologous stem cell transplantation; survival; treatment; ACUTE MYELOGENOUS LEUKEMIA; BONE-MARROW-TRANSPLANTATION; 1ST REMISSION; CONSOLIDATION CHEMOTHERAPY; INTENSIVE CHEMOTHERAPY; BLOOD; MANAGEMENT;
D O I
10.4149/neo_2013_022
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: the role of autologous stem cell transplantation (ASCT) in treatment of acute myeloid leukemia (AML) remains unsettled. Aims: retrospective analysis to evaluate the role of ASCT in patients with AML without HLA-matched donor. Methods: between December 19, 1994 and August 1, 2012, a total of 63 patients with AML without HLA-matched donor in the department of Hematology and Transfusion Medicine, University Hospital, Bratislava, received an ASCT. Median age was 41 years (20-61 years). There were 35 (56%) males and 28 (44%) females. At the time of ASCT, 50 (79%) patients were in first complete remission (CR), 11(18%) patients were in second CR and 2 (3%) patients were in relapse. Results: with a median follow-up of 115 months (34-214 months), the 10 year overall survival (OS) and disease free survival (DFS) of all patients was 55% and 51%, respectively. Transplant-related mortality was 6%. The relapse rate was 38% and 9 years probability of relapse was 44%. Conclusion: ASCT is still an effective post-remission treatment in AML patients without HLA-matched donor; with the possibility of long-term survival or even cure in remarkable proportion of patients with AML, particularly in patients with favorable and intermediate cytogenetic risk.
引用
收藏
页码:167 / 173
页数:7
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