Synthesis, Characterization and Antimicrobial Activity of Potential Bioactive Organotin(IV) Dithiocarboxylates

被引：0

作者：

Abbas, Syed Mustansar ^{[1
,2
]}

Sirajuddin, Muhammad ^{[1
]}

Shah, Farooq Ali ^{[1
]}

Ali, Saqib ^{[1
]}

Ahmad, Sajjad ^{[1
]}

机构：

[1] Quaid I Azam Univ, Dept Chem, Islamabad 45320, Pakistan

[2] Natl Ctr Phys, Nanosci & Catalysis Div, Islamabad, Pakistan

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 05期

关键词：

Organotin(IV) dithiocarboxylate; Antibacterial activity; Antifungal activity; CALF THYMUS DNA; X-RAY-STRUCTURE; BIOLOGICAL SCREENINGS; SPECTROSCOPIC CHARACTERIZATION; COMPLEXES; ANTIBACTERIAL; DECOMPOSITION; LIGAND;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of newly synthesized organotin(IV) compounds; Me2SnClL (1) Bu2SnClL (2), Ph2SnClL (3), Me3SnL (4), Ph3SnL (5) have been derived from the reaction of organotin(IV) chlorides with 4-formylpiperazinium 4-formylpiperazine-1-carbodithioate (L) in the appropriate molar ratio. Their spectroscopic investigations have been carried out in solution state. Based on spectroscopic results, the ligand appeared to coordinate to the Sn atom through the CSS moiety. Bioassay results have revealed that these compounds have good antibacterial and antifungal activities and may well be the basis for a new class of antimicrobial drugs. The triorganotin(IV) derivatives in particular, were found to be more active than diorganotin(IV) compounds.

引用

页码：1399 / 1407

页数：9

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