1H MR spectroscopy in patients with mesial temporal epilepsy

被引:0
|
作者
Hajek, Milan [1 ]
Dezortova, Monika [1 ]
Komarek, Vladimir [2 ]
机构
[1] Inst Clin & Expt Med, Magnet Resonance Unit, Dept Diagnost & Intervent Radiol, Prague 14000, Czech Republic
[2] Charles Univ Prague, Motol Teaching Hosp, Dept Pediat Neurol, Prague, Czech Republic
关键词
H-1; MRS; Epilepsy; Mesial temporal sclerosis; Atrophy; Review;
D O I
暂无
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The study provides a review of the basic examination procedures and results of proton magnetic resonance spectroscopy (H-1 MRS) in patients suffering from mesial temporal lobe epilepsy (MTLE). The source of seizures in MTLE is most often an epileptogenic focus secondary to hippocampal sclerosis. H-1 MRS currently plays an important role in the non-invasive diagnosis of this type of epileptogenic lesion. The decisive H-1 MRS parameter characterizing an epileptogenic lesion is a statistically significantly decreased value of N-acetylaspartate levels compared with control values, most often associated with a decrease in the ratios of the intensities of NAA/Cr, NAA/Cho and NAA/(Cr + Cho) signals. Moreover, MRS makes it possible to distinguish bilateral involvement of mesial temporal structures typically associated with a bilateral decrease in the levels of metabolites and/or their ratios. As regards other metabolic compounds which play an important role in the pathobiochemistry of epilepsy, MRS is employed to study the action of gamma-aminobutyric acid (GABA), inositol, lactate, glutamine, and glutamate, the clinical function of which has not been fully clarified as yet. It is in this context that one should consider the application of H-1 MRS in evaluating the action of some new anti-epileptic agents affecting excitatory and inhibitory amino acids. There is no doubt that in vivo H-1 MRS, along with other imaging methods, has made a significant contribution to the clinical and biochemical description of epileptic seizures and has assumed a prominent position among the techniques of pre-operative examination in epileptic surgery. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:95 / 114
页数:20
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