Measuring iron in the brain using quantitative susceptibility mapping and X-ray fluorescence imaging

被引：133

作者：

Zheng, Weili ^{[1
]}

Nichol, Helen ^{[2
]}

Liu, Saifeng ^{[3
]}

Cheng, Yu-Chung N. ^{[1
]}

Haacke, E. Mark ^{[1
,3
]}

机构：

[1] Wayne State Univ, HUH MR Res Radiol, Detroit, MI 48201 USA

[2] Univ Saskatchewan, Dept Anat & Cell Biol, Saskatoon, SK, Canada

[3] McMaster Univ, Sch Biomed Engn, Hamilton, ON, Canada

来源：

NEUROIMAGE | 2013年 / 78卷

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Brain iron; Ferritin; Quantitative susceptibility mapping (QSM); X-ray fluorescence imaging (XRF); HIGH-FIELD MRI; NON-HAEMIN IRON; MAGNETIC-RESONANCE; TRANSVERSE RELAXATION; MULTIPLE-SCLEROSIS; SPATIAL VARIATION; CEREBRAL-CORTEX; TISSUE; CONTRAST; FERRITIN;

D O I：

10.1016/j.neuroimage.2013.04.022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Measuring iron content in the brain has important implications for a number of neurodegenerative diseases. Quantitative susceptibility mapping (QSM), derived from magnetic resonance images, has been used to measure total iron content in vivo and in post mortem brain. In this paper, we show how magnetic susceptibility from QSM correlates with total iron content measured by X-ray fluorescence (XRF) imaging and by inductively coupled plasma mass spectrometry (ICPMS). The relationship between susceptibility and ferritin iron was estimated at 1.10 +/- 0.08 ppb susceptibility per mu g iron/g wet tissue, similar to that of iron in fixed (frozen/thawed) cadaveric brain and previously published data from unfixed brains. We conclude that magnetic susceptibility can provide a direct and reliable quantitative measurement of iron content and that it can be used clinically at least in regions with high iron content. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：68 / 74

页数：7

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