Programmable drug release using bioresponsive mesoporous silica nanoparticles for site-specific oral drug delivery

被引：63
|
作者：
Popat, Amirali [1 ,2 ,3 ]
Jambhrunkar, Siddharth [1 ]
Zhang, Jun [1 ]
Yang, Jie [1 ]
Zhang, Honwei [1 ]
Meka, Anand [1 ]
Yu, Chengzhong [1 ]
机构：
[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia
[2] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia
[3] Univ Queensland, Translat Res Inst, Mater Res Inst, Mucosal Dis Grp, Woolloongabba, Qld 4102, Australia
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 42期
基金：
英国医学研究理事会; 澳大利亚研究理事会;
关键词：
RESPONSIVE CONTROLLED-RELEASE; GUEST MOLECULES; PH; ENZYME; SYSTEM; PARTICLES; SUPPORTS; CARRIER; CARGO; CELLS;
D O I：
10.1039/c4cc00620h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel mesoporous silica nanoparticles (MSNs) responsive to multiple biological stimuli (pH and enzymes) were prepared through conjugation with a structure modified soy protein isolate. The particles show an extremely high pro-drug (sulfasalazine) loading with programmable drug release in simulated gastrointestinal fluid.
引用
收藏
页码：5547 / 5550
页数：4
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